Inventors:
Anna Berkenblit - Cambridge MA, US
Christina Marie Coughlin - Berwyn PA, US
Jay Marshall Feingold - Livingston NJ, US
Daniel Stephen Johnston - Collegeville PA, US
Andrew Louis Strahs - Maynard MA, US
Charles Michael Zacharchuk - Cambridge MA, US
International Classification:
A61K 39/395, A61K 45/06, A61K 31/4709
US Classification:
4241451, 435 612, 435 614, 506 9, 514313
Abstract:
Methods for treating breast cancer, specifically cancers resistant to treatment with one or more known breast cancer treatment drugs, and related patient selection strategies for predicting patient response to drug therapy, such strategies including detecting the presence or absence in a patient of one or more of PIK3CA gene amplification, a mutation in PIK3CA, and a decrease in PTEN protein expression, and treating a patient positive for the presence of one or more of same by administering to the subject a pan-ErbB tyrosine kinase inhibitor.