Inventors:
Ronald G. Crystal - New York NY, US
Neil R. Hackett - New York NY, US
Adriana Heguy - Forest Hills NY, US
Ben-Gary Harvey - West Hempstead NY, US
Philip L. Leopold - Basking Ridge NJ, US
Ann E. Tilley - New York NY, US
Timothy O'Connor - New York NY, US
Assignee:
Cornell University - Ithaca NY
International Classification:
A61K 38/20, G01N 33/53, A61K 38/45, A61K 38/47, A61K 38/44, A61K 38/21, A61P 11/00
US Classification:
424 852, 435 721, 424 945, 424 9461, 424 944, 424 855
Abstract:
The invention provides a method of determining the likelihood that a smoker will or will not develop chronic obstructive pulmonary disease (COPD) by obtaining a sample from the smoker, analyzing the sample for the expression of a set of biomarkers associated with COPD, and comparing the expression pattern determined in the sample with a standard expression pattern to determine the likelihood that the smoker will or will not develop COPD. The invention further provides a composition, a method of treatment, and methods of determining the efficacy of treatment for COPD.