Inventors:
Dennis A. Holt - Mohnton PA
Conrad J. Kowalski - Paoli PA
Mark A. Levy - Wayne PA
Brian W. Metcalf - Radnor PA
Ann M. Tickner - Philadelphia PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 3158, A61K 3156, C07J 7100, C07J 1700
Abstract:
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-. alpha. -reductase. Also invented are intermediates used in preparing these compounds.