Inventors:
Yoshihiko Murata - Pittsford NY, US
Robert C. Rose - Geneseo NY, US
Edward E. Walsh - Pittsford NY, US
Ann R. Falsey - Rochester NY, US
Assignee:
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
A61K 39/155, C07K 14/025, C12N 15/63, C12N 1/00, C12P 21/02, A61K 39/12, C07K 1/00, C07K 14/135, A61P 37/04, A61P 31/20, A61P 31/14
US Classification:
4241921, 530350, 4353201, 435243, 435 697, 42419611, 530402
Abstract:
The present invention is directed to a chimeric papillomavirus virus-like particle (VLP) or capsomere including an L1 polypeptide and, optionally, an L2 polypeptide, and a respiratory syncytial virus (RSV) protein or polypeptide fragment thereof comprising a first epitope, where the RSV protein or polypeptide fragment thereof is attached to one or both of the L1 and L2 polypeptides. Chimeric proteins, genetic constructions, and recombinant vectors and host cells suitable for expression of the constructs and making of the chimeric VLPs or capsomeres are also disclosed. Use of the VLPs or capsomeres, or a pharmaceutical composition containing the same, is contemplated for inducing a protective immune response against RSV.