Inventors:
David Agus - Beverly Hills CA, US
Anjali Jain - Los Angeles CA, US
Michael Hedvat - Encino CA, US
Assignee:
CEDARS-SINAI MEDICAL CENTER - Los Angeles CA
International Classification:
A61K 39/395, A61K 31/60, A61K 31/405, A61K 31/192
US Classification:
424146100, 514165000, 514420000, 514569000, 514570000
Abstract:
Described herein are methods of using a NSAID and a HER-kinase axis inhibitor in the treatment of various conditions including cancer, and especially prostate, breast, lung, ovarian, brain and colon cancers, through regulation of PPARĪ³ activity. In various embodiments, the NSAID and HER-kinase axis inhibitor may be included in a composition that is useful for the treatment of conditions in a mammal. Also described is a kit including a NSAID and a HER-kinase axis inhibitor along with instructions for their use in treating and preventing disease conditions, such as cancer.