Inventors:
David Agus - Beverly Hills CA, US
Anjali Jain - Los Angeles CA, US
Michael Hedvat - Encino CA, US
Assignee:
CEDARS-SINAI MEDICAL CENTER - Los Angeles CA
International Classification:
A61K 39/395, A61K 31/60, A61K 31/405, A61K 31/192
US Classification:
424146100, 514165000, 514420000, 514569000, 514570000
Abstract:
Described herein are methods of using a NSAID and a HER-kinase axis inhibitor in the treatment of various conditions including cancer, and especially prostate, breast, lung, ovarian, brain and colon cancers, through regulation of PPARγ activity. In various embodiments, the NSAID and HER-kinase axis inhibitor may be included in a composition that is useful for the treatment of conditions in a mammal. Also described is a kit including a NSAID and a HER-kinase axis inhibitor along with instructions for their use in treating and preventing disease conditions, such as cancer.