Inventors:
Beth L. Laube - Baltimore MD
G. Kenneth Adams - Bloomfield NJ
Angeliki Georgopoulos - Minneapolis MN
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
A61M 1500, A61M 1610, A61M 1100, A62B 700
Abstract:
A method of delivering a protein, in particular insulin, to the lungs. The method is characterized in that an aerosolized mist of small particles is produced in an associated medicament delivery chamber, the distance from the chamber to the patient's mouth is set to slow the speed of aerosol particles entering the mouth and the flow rate through the chamber is regulated to a low rate of less than about 30 liters per minute. It has been found that administering insulin in accordance with the invention may advantageously produce a penetration of medication into the lungs of about 90%.