Angela Maria Sanguino Ramirez
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MT202941
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
Pittsburgh, PA 15219
Professional information
Methods And Compositions Related To Wrapping Of Dehydrons
US Patent:
2013013, May 23, 2013
Filed:
Oct 29, 2007
Appl. No.:
11/927329
Inventors:
Ariel Fernandez - Houston TX, US
William Bornmann - Missouri City TX, US
Angela Sanguino - Pittsburgh PA, US
Zheng-Hong Peng - Missouri City TX, US
Anil K. Sood - Pearland TX, US
William Bornmann - Missouri City TX, US
Angela Sanguino - Pittsburgh PA, US
Zheng-Hong Peng - Missouri City TX, US
Anil K. Sood - Pearland TX, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
A61K 31/506
US Classification:
51425218, 544295
Abstract:
This application describes a novel technology in drug discovery and drug-based imaging/detection: the wrapping technology. This technology is based on identified singularities in the structure of soluble proteins. In contrast with drug-design approaches based on standard structural considerations, the packing of a protein, or more precisely, its dehydron pattern, may be used as a selectivity filter to design small-molecule inhibitors. The wrapping technology described herein is a novel form of rational drug design for avoiding side effects in drug therapy and sharpening the inhibitory impact of drugs on the oncokinome.