ANGELA M PUIA
Medical Practice at 86, Miami, FL
License number
Florida 43273
Issued Date
Nov 5, 2010
Effective Date
Nov 5, 2010
Expiration Date
Aug 31, 2018
Category
Health Care
Type
Clinical Laboratory Personnel
Address
Address
7715 SW 86Th St APT 201, Miami, FL 33143
Phone
(914) 246-7922
Professional information
Troponin I Forms And Use Of The Same
US Patent:
6248869, Jun 19, 2001
Filed:
May 29, 1997
Appl. No.:
8/865468
Inventors:
Nihmat A. Morjana - Pembroke Pines FL
Angela M. Puia - Miami FL
Angela M. Puia - Miami FL
Assignee:
Medical Analysis Systems, Inc. - Camarillo CA
International Classification:
C07K 1300
US Classification:
530841
Abstract:
The present invention relates to an isolated fragment of human cardiac troponin I (TnI) comprising the following sequence
X-A-B-Y
wherein
X comprises any of amino acid residues 1-27 of SEQ ID NO: 2;
A comprises amino acid residues 28-69 of SEQ ID NO: 2;
B comprises amino acid residues 70-90 of SEQ ID NO: 2;
and Y comprises any of amino acid residues 91-170 of SEQ ID NO: 2. The present invention further relates to fragments of TnI wherein the fragment has a greater immunologic reactivity than intact cTnI when the fragment and intact cTnI are reacted with a monoclonal antibody, which has an epitopic site on the fragment.