Inventors:
Jordan Kopping - Weinheim, DE
Kalpesh Biyani - Fremont CA, US
Eric Connor - Los Gatos CA, US
Scott Hecker - Del Mar CA, US
Inez Lees - Mountain View CA, US
Grace Quaker - San Francisco CA, US
Faleh Salaymeh - Sunnyvale CA, US
Hongmin Zhang - Fremont CA, US
David Bergbreiter - College Station TX, US
Paul Mansky - San Francisco CA, US
YongQi Mu - Los Altos CA, US
Michael James Cope - Berkeley CA, US
Elizabeth Goka - San Jose CA, US
Angela Lee - San Jose CA, US
Deidre Madsen - Los Altos CA, US
Jun Shao - Fremont CA, US
Assignee:
RELYPSA, INC. - Santa Clara CA
International Classification:
C08F 226/02, A61P 3/06, A61K 31/785
Abstract:
The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.