ANDREW ZALEWSKI
Medical Practice in Melrose Park, PA
License number
Pennsylvania MD031595E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Melrose Park, PA 19027
Personal information
See more information about ANDREW ZALEWSKI at radaris.comName
Address
Phone
619 Elkins Ave, Elkins Park, PA 19027
47 Split Rock Rd, Elkins Park, PA 19027
47 Split Rock Rd, Lake Harmony, PA 18624
619 Elkins Ave, Elkins Park, PA 19027
Organization information
See more information about ANDREW ZALEWSKI at bizstanding.comDr Andrew Zalewski
619 Elkins Ave, Melrose Park, PA 19027
Industry:
Medical Doctor's Office
Principals:
Andrzej Zalewski (Principal),Andrew Zalewski Principal, inactive
Professional information
Inhibition Of Cell Proliferation And Matrix Synthesis By Antioxidants And Nad(P)H Oxidase Inhibitors
US Patent:
2002002, Feb 21, 2002
Filed:
May 21, 2001
Appl. No.:
09/861957
Inventors:
Yi Shi - Cheltenham PA, US
Andrew Zalewski - Elkins Park PA, US
Andrew Zalewski - Elkins Park PA, US
International Classification:
A61K038/44, A61K031/198, A61K038/06, A61K031/40
US Classification:
424/094400, 514/018000, 514/423000, 514/562000
Abstract:
The present invention is directed to a method for the prophylactic and therapeutic treatment of diseases or disorders associated with the abnormal proliferation and extracellular matrix synthesis of smooth muscle cells (SMC) and fibroblasts due to activation of NAD(P)H and/or increased ROS generation. The method involves the administration of an NAD(P)H oxidase inhibitor(s) and/or antioxidant(s) to a mammal in an amount sufficient to treat the disease or disorder prophylactically or therapeutically. The NAD(P)H oxidase inhibitor inhibits the synthesis or translocation of NAD(P)H subunits, thereby blocking the generation of intracellular reactive oxygen species (ROS) and thus the proliferation and extracellular matrix synthesis of SMC and fibroblasts. Similarly, the administration of antioxidants blocks the generation of intracellular ROS, thereby inhibiting SMC and fibroblast proliferation and extracellular matrix synthesis. In addition to the prevention and treatment of vascular disease, such as atherosclerosis, graft disease, and restenosis, NAD(P)H oxidase inhibitors and antioxidants may be useful for the prevention and treatment of other conditions by decreasing cell proliferation and extracellular matrix synthesis associated therewith. These conditions include arthritis, keloid formation, cancer, tissue and organ fibrosis, and complications related to organ transplantation, metabolic syndrome, and radiation therapy.
Antisense Inhibition Of C-Myc To Modulate The Proliferation Of Smooth Muscle Cells
US Patent:
6159946, Dec 12, 2000
Filed:
Jul 7, 1995
Appl. No.:
8/481341
Inventors:
Andrew Zalewski - Elkins Park PA
Yi Shi - Cheltenham PA
Yi Shi - Cheltenham PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
C07H 2104, A61K 4800
US Classification:
514 44
Abstract:
The present invention provides antisense therapies useful for modulating smooth muscle cell proliferation. Methods of treating and preventing restenosis are also provided.
Inhibition Of Extracellular Matrix Synthesis By Antisense Compounds Directed To Nuclear Proto-Oncogenes
US Patent:
6133242, Oct 17, 2000
Filed:
Jun 5, 1995
Appl. No.:
8/461366
Inventors:
Andrew Zalewski - Elkins Park PA
Yi Shi - Cheltenham PA
Yi Shi - Cheltenham PA
Assignee:
Thomas Jefferson Univerisity - Philadelphia PA
International Classification:
A61K 4800, C07H 2104, C07H 2102, C12Q 168
US Classification:
514 44
Abstract:
A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise antisense oligonucleotides specific for nuclear proto-oncogenes. Preferably, antisense compounds of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.
Arteriovenous And Venous Graft Treatments: Methods And Compositions
US Patent:
6323184, Nov 27, 2001
Filed:
Apr 19, 1995
Appl. No.:
8/424991
Inventors:
Andrew Zalewski - Elkins Park PA
Yi Shi - Cheltenham PA
Yi Shi - Cheltenham PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 4800, C07H 2104
US Classification:
514 44
Abstract:
A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise oligonucleotides specific for nuclear proto-oncogenes. Preferably, oligonucleotides of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.