Inventors:
C. David Allis - Princeton NJ, US
Andrew Xiao - New York NY, US
Assignee:
THE ROCKEFELLER UNIVERSITY - New York NY
International Classification:
A61K 39/395, C07K 16/00, C07K 14/00, C07H 21/00, C12N 15/74, C12N 1/21, C12Q 1/68, G01N 33/53, C12N 5/071, A61K 31/7105, A61K 38/46, A61K 31/711, A61P 35/00
US Classification:
4241301, 5303871, 5303881, 5303891, 5303873, 530350, 536 231, 4353201, 4352533, 435 6, 435 72, 435325, 514 44 A, 424 946, 514 44 R
Abstract:
The present invention relates to methods of detecting and regulating cellular DNA damage as well as methods of screening compounds suitable for modulating cellular DNA damage. The methods of the present invention utilize antibodies that selectively bind to a phosphorylated tyrosine residue in a SQEY tyrosine phosphorylation motif sequence or a phosphorylated serine residue in a KENSSQ phosphorylation motif sequence, where the phosphorylated serine residue is closest to the glutamine residue. Also encompassed by the present invention are methods of treating a subject having cancer. These methods involve the administration of an agent that modulates the phosphorylation of the tyrosine residue in a SQEY motif. Suitable agents for modulating the phosphorylation of the tyrosine residue of the SQEY motif are also disclosed.