ANDREW JONATHAN GHIO
Medical Practice in Durham, NC

5512270, Apr 30, 1996

Aug 31, 1994

8/299316

Andrew J. Ghio - Durham NC
Claude A. Piantadosi - Durham NC
Thomas P. Kennedy - Richmond VA

Duke University - Durham NC

A61K 31045

424 45

The present invention relates to use of alkylaryl polyether alcohol polymers as antioxidants to suppress certain oxidant chemical reactions that cause tissue injury and disease in mammals. Disclosed is a method of inhibiting oxidants using alkylaryl polyether alcohol polymers. More particularly, disclosed is a method for the treatment of mammalian disease entities related to overproduction of partially reduced oxygen species comprising administering to a mammal a treatment effective amount of an alkylaryl polyether alcohol polymer. The mammalian disease entities include, but are not limited to, myocardial infarction, stroke, adult respiratory distress syndrome, oxygen toxicity of the lung, lung injury from asbestos, Parkinson's disease, thermal and solar burns of the skin, and injury to the gastrointestinal tract from nonsteroidal anti-inflammatory agents.

6024940, Feb 15, 2000

Jun 16, 1998

9/097929

Andrew J. Ghio - Durham NC
Thomas P. Kennedy - Richmond VA

Charlotte-Mecklenburg Hospital Authority - Charlotte NC

A61K 912, A61K 31765

424 45

A method and medicant for the inhibition of activation of the nuclear transcription NF-. kappa. B comprising administering an effective amount of a compound of the formula: ##STR1## where R=ethylene, R'=C. sub. 4 to C. sub. 14 straight chain or branched alkyl, x is greater than 1, and y=8 to 18 is provided. The medicant is preferably administered by aerosolization into the mammalian respiratory system. The medicant may also be applied to the mammalian skin. Preferably the medicant includes a physiologically acceptable carrier which may be selected from buffered saline, isotonic saline, normal saline, petroleum-based ointments and U. S. P. cold cream. There is further provided a method wherein the medicant includes an anti-inflammatory steroid. In addition a method and medicant for treating cutaneous inflammatory disorders, inhibiting the secretion of the pro-inflammatory cytokines TNF, IL-1, IL-6, IL-8 and the growth factor GM-CSF is provided.

5840277, Nov 24, 1998

Apr 15, 1996

8/632275

Andrew J. Ghio - Durham NC
Thomas P. Kennedy - Richmond VA

Charlotte Hospital Authority - Charlotte NC

A61K 912, A61K 31765

424 45

A method and medicant for the inhibition of activation of the nuclear transcription NF-. kappa. B comprising administering an effective amount of a compound of the formula: ##STR1## where R=ethylene, R'=C. sub. 4 to C. sub. 14 straight chain or branched alkyl, x is greater than 1, and y=8 to 18 is provided. The medicant is preferably administered by aerosolization into the mammalian respiratory system. The medicant may also be applied to the mammalian skin. Preferably the medicant includes a physiologically acceptable carrier which may be selected from buffered saline, isotonic saline, normal saline, petroleum-based ointments and U. S. P. cold cream. There is further provided a method wherein said medicant includes an anti-inflammatory steroid. In addition a method and medicant for treating cutaneous inflammatory disorders, inhibiting the secretion of the pro-inflammatory cytokines TNF, IL-1, IL-6, IL-8 and the growth factor GM-CSF is provided.

5830436, Nov 3, 1998

Mar 30, 1995

8/413699

Andrew J. Ghio - Durham NC
Thomas P. Kennedy - Richmond VA

Duke University - Durham NC

A61K 912

424 45

A method and medicament for the inhibition of oxidants comprising administering a treatment effective amount of alkylaryl polyether alcohol polymers to a chemical or biologic system in need thereof. Also, a method and medicament for mucociliary clearance, inhibition of cytokine production, and inhibition of interleukin-8 production in cystic fibrosis patients. The method involves administering a treatment effective amount of alkylaryl polyether alcohol polymers to a chemical or biologic system in need thereof. The medicament is preferably administered by aerosolization into the mammalian respiratory system. The medicament may also be applied to the mammalian skin. Preferably, the medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, isotonic saline, normal saline, petrolatum based ointments and U. S. P. cold cream.

5474760, Dec 12, 1995

Mar 29, 1994

8/219770

Andrew J. Ghio - Durham NC
Claude A. Piantadosi - Durham NC
Thomas P. Kennedy - Richmond VA

Duke University - Durham NC

A61K 912, A61K 31765

424 45

A method and medicament for the inhibition of oxidants comprising administering a treatment effective amount of alkylaryl polyether alcohol polymers to a chemical or biologic system in need thereof. The medicament is preferably administered by aerosolization into the mammalian respiratory system. The medicament may also be applied to the mammalian skin. Preferably, the medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, isotonic saline, normal saline, petrolatum based ointments and U. S. P. cold cream.