ANDREW H SEGAL, M.D.
Osteopathic Medicine at Emerson Pl, Boston, MA
License number
Massachusetts 234543
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
1 Emerson Pl APARTMENT 9H, Boston, MA 02114
Phone
(617) 777-5083
Professional information
Methods Of Modulating An Immune Response To Antigen, And Cells For Use In The Method
US Patent:
6403080, Jun 11, 2002
Filed:
Jun 24, 1999
Appl. No.:
09/339523
Inventors:
Andrew H. Segal - Boston MA
Assignee:
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
A01N 6300
US Classification:
424 931, 424 932, 424 9321, 424 937, 424 9371, 4241361, 435325, 514 2, 514 12, 5303873
Abstract:
Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to express higher levels of an endogenous opsonin, or 3) mixed with an exogenous opsonin, when administered to a subject, modulate the immune response in the recipient to a selected antigen or antigens contained in or attached to the cells.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004012, Jul 1, 2004
Filed:
Sep 19, 2003
Appl. No.:
10/666886
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
A61K048/00, A61K039/00, A61K038/19
US Classification:
424/085100, 424/093200, 424/185100
Abstract:
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.
Nucleic Acid Compositions And Methods Of Introducing Nucleic Acids Into Cells
US Patent:
2005015, Jul 14, 2005
Filed:
Oct 7, 2004
Appl. No.:
10/960128
Inventors:
Andrew Segal - Boston MA, US
Jeffrey Wilson - Brighton MA, US
Jeffrey Wilson - Brighton MA, US
International Classification:
C12Q001/68, C07H021/04, C12N015/85
US Classification:
435006000, 435455000, 435320100, 435325000, 536023200
Abstract:
The invention relates to a bifunctional nucleic acid which includes a first nucleic acid which comprises an aptamer bonded to a second nucleic acid that possesses a biological activity (herein referred to as a “biological effector sequence”) and which is not a nucleic acid ligand.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004012, Jun 24, 2004
Filed:
Sep 19, 2003
Appl. No.:
10/666871
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
C07K014/705
US Classification:
530/395000, 514/008000
Abstract:
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2005006, Mar 24, 2005
Filed:
Sep 19, 2003
Appl. No.:
10/668073
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
International Classification:
C12Q001/70, G01N033/574, G01N033/567, G01N033/53, G01N031/00
US Classification:
435005000, 436005000, 435007100, 435007200, 435007230
Abstract:
The present invention also relates to a method of reducing metastases in a subject comprising administering to the subject a composition comprising a multifunctional molecule comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004024, Dec 2, 2004
Filed:
Sep 19, 2003
Appl. No.:
10/666833
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
A61K039/00, A61K038/19, A61K038/20
US Classification:
424/085100, 424/085200, 424/192100
Abstract:
The present invention also relates to a method of reducing metastases in a subject comprising administering to the subject a composition comprising a multifunctional molecule comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell.
Vaccine Compositions And Methods Of Modulating Immune Responses
US Patent:
6224870, May 1, 2001
Filed:
Jan 15, 1998
Appl. No.:
9/007711
Inventors:
Andrew H. Segal - Boston MA
Assignee:
Genitrix, Ltd. - Cambridge MA
International Classification:
A61K 3900, A61K 3170, A01N 4304
US Classification:
4241921
Abstract:
The invention provides compositions and methods for modulating immune responses in subjects. The invention is based, at least in part, on the discovery that an in-frame translation fusion of an antigen with an APC binding domain of an opsonin forms a molecule, that is, a fusion polypeptide, which when administered to a subject modulates an immune response to the antigen.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004009, May 13, 2004
Filed:
Aug 20, 2003
Appl. No.:
10/645000
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
A61K039/00, A61K039/12, A61K039/02, A61K039/002
US Classification:
424/192100, 424/198100, 424/204100, 424/234100, 424/265100, 424/274100, 424/277100
Abstract:
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.
Opsonin-Enhanced Cells, And Methods Of Modulating An Immune Response To An Antigen
US Patent:
5951976, Sep 14, 1999
Filed:
Mar 27, 1997
Appl. No.:
8/826259
Inventors:
Andrew H. Segal - Boston MA
Assignee:
Whitenead Institute for Biomedical Research - Cambridge MA
International Classification:
A61K 3800, C12N 900, C12N 506, A01N 6300
US Classification:
424 9321
Abstract:
Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to express higher levels of an endogenous opsonin, or 3) mixed with an exogenous opsonin, when administered to a subject, modulate the immune response in the recipient to a selected antigen or antigens contained in or attached to the cells.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004018, Sep 16, 2004
Filed:
Sep 19, 2003
Appl. No.:
10/667166
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
G01N033/574, C07K016/46
US Classification:
435/007230, 530/388800, 530/395000
Abstract:
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.