ANDREW H SEGAL, M.D.
Osteopathic Medicine at Emerson Pl, Boston, MA
License number
Massachusetts 234543
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
1 Emerson Pl APARTMENT 9H, Boston, MA 02114
Phone
(617) 777-5083
Personal information
See more information about ANDREW H SEGAL at radaris.comName
Address
Phone
45 Cedar St #1, Malden, MA 02148
28 Trident Ave, Winthrop, MA 02152
46 Leonard Ln, Norwell, MA 02061
1 Emerson Pl APT 9H, Boston, MA 02114
217 Salem St, Wakefield, MA 01880
Professional information
See more information about ANDREW H SEGAL at trustoria.com
Methods Of Modulating An Immune Response To Antigen, And Cells For Use In The Method
Methods Of Modulating An Immune Response To Antigen, And Cells For Use In The Method
US Patent:
6403080, Jun 11, 2002
Filed:
Jun 24, 1999
Appl. No.:
09/339523
Inventors:
Andrew H. Segal - Boston MA
Assignee:
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
A01N 6300
US Classification:
424 931, 424 932, 424 9321, 424 937, 424 9371, 4241361, 435325, 514 2, 514 12, 5303873
Abstract:
Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to express higher levels of an endogenous opsonin, or 3) mixed with an exogenous opsonin, when administered to a subject, modulate the immune response in the recipient to a selected antigen or antigens contained in or attached to the cells.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004012, Jul 1, 2004
Filed:
Sep 19, 2003
Appl. No.:
10/666886
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
A61K048/00, A61K039/00, A61K038/19
US Classification:
424/085100, 424/093200, 424/185100
Abstract:
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.
Nucleic Acid Compositions And Methods Of Introducing Nucleic Acids Into Cells
Nucleic Acid Compositions And Methods Of Introducing Nucleic Acids Into Cells
US Patent:
2005015, Jul 14, 2005
Filed:
Oct 7, 2004
Appl. No.:
10/960128
Inventors:
Andrew Segal - Boston MA, US
Jeffrey Wilson - Brighton MA, US
Jeffrey Wilson - Brighton MA, US
International Classification:
C12Q001/68, C07H021/04, C12N015/85
US Classification:
435006000, 435455000, 435320100, 435325000, 536023200
Abstract:
The invention relates to a bifunctional nucleic acid which includes a first nucleic acid which comprises an aptamer bonded to a second nucleic acid that possesses a biological activity (herein referred to as a “biological effector sequence”) and which is not a nucleic acid ligand.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004012, Jun 24, 2004
Filed:
Sep 19, 2003
Appl. No.:
10/666871
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
C07K014/705
US Classification:
530/395000, 514/008000
Abstract:
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2005006, Mar 24, 2005
Filed:
Sep 19, 2003
Appl. No.:
10/668073
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
International Classification:
C12Q001/70, G01N033/574, G01N033/567, G01N033/53, G01N031/00
US Classification:
435005000, 436005000, 435007100, 435007200, 435007230
Abstract:
The present invention also relates to a method of reducing metastases in a subject comprising administering to the subject a composition comprising a multifunctional molecule comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004024, Dec 2, 2004
Filed:
Sep 19, 2003
Appl. No.:
10/666833
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
A61K039/00, A61K038/19, A61K038/20
US Classification:
424/085100, 424/085200, 424/192100
Abstract:
The present invention also relates to a method of reducing metastases in a subject comprising administering to the subject a composition comprising a multifunctional molecule comprising a first part which is capable of binding to an antigen bearing target and a second part which is capable of binding to a cell.
Vaccine Compositions And Methods Of Modulating Immune Responses
Vaccine Compositions And Methods Of Modulating Immune Responses
US Patent:
6224870, May 1, 2001
Filed:
Jan 15, 1998
Appl. No.:
9/007711
Inventors:
Andrew H. Segal - Boston MA
Assignee:
Genitrix, Ltd. - Cambridge MA
International Classification:
A61K 3900, A61K 3170, A01N 4304
US Classification:
4241921
Abstract:
The invention provides compositions and methods for modulating immune responses in subjects. The invention is based, at least in part, on the discovery that an in-frame translation fusion of an antigen with an APC binding domain of an opsonin forms a molecule, that is, a fusion polypeptide, which when administered to a subject modulates an immune response to the antigen.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004009, May 13, 2004
Filed:
Aug 20, 2003
Appl. No.:
10/645000
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
A61K039/00, A61K039/12, A61K039/02, A61K039/002
US Classification:
424/192100, 424/198100, 424/204100, 424/234100, 424/265100, 424/274100, 424/277100
Abstract:
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.
Opsonin-Enhanced Cells, And Methods Of Modulating An Immune Response To An Antigen
Opsonin-Enhanced Cells, And Methods Of Modulating An Immune Response To An Antigen
US Patent:
5951976, Sep 14, 1999
Filed:
Mar 27, 1997
Appl. No.:
8/826259
Inventors:
Andrew H. Segal - Boston MA
Assignee:
Whitenead Institute for Biomedical Research - Cambridge MA
International Classification:
A61K 3800, C12N 900, C12N 506, A01N 6300
US Classification:
424 9321
Abstract:
Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to express higher levels of an endogenous opsonin, or 3) mixed with an exogenous opsonin, when administered to a subject, modulate the immune response in the recipient to a selected antigen or antigens contained in or attached to the cells.
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
Lectin Compositions And Methods For Modulating An Immune Response To An Antigen
US Patent:
2004018, Sep 16, 2004
Filed:
Sep 19, 2003
Appl. No.:
10/667166
Inventors:
Andrew Segal - Boston MA, US
Elihu Young - Sharon MA, US
Elihu Young - Sharon MA, US
Assignee:
Genitrix, LLC
International Classification:
G01N033/574, C07K016/46
US Classification:
435/007230, 530/388800, 530/395000
Abstract:
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.