ANDREW G PLAUT, MD
Osteopathic Medicine at Washington St, Boston, MA

6825169, Nov 30, 2004

Oct 15, 1997

08/950542

William W. Bachovchin - Melrose MA
Andrew G. Plaut - Boston MA
George R. Flentke - Boston MA

Trustees of Tufts College - Medford MA

C07K 506

514 19, 568 1, 514 15, 514 16, 514 17, 514 18, 530327, 530328, 530329, 530330, 530331

An inhibitory compound having the structure: Group I-Group II. Group I has the structure: where H represents a hydrogen; C represents a carbon; O represents an oxygen; N represents a nitrogen; each R, independently, is chosen from the group consisting of the R groups of an amino acid, including proline; each broken line, independently, represents a bond to an H or a bond to one R group, and each H′ represents that bond or a hydrogen; and p is an integer between 0 and 4 inclusive. Alternatively Group I has the structure: where n is between 0 and 3 inclusive, each G2 and G3 independently is H or C1-3 (one to three carbon atoms) alkyl, G1 is NH3 (H3 represents three hydrogens), (H2 represents two hydrogens), or where G5 and G6 can be NH, H, or C1-3 alkyl or alkenyl with one or more carbons substituted with a nitrogen. G1 bears a charge, and G1 and Group II do not form a covalently bonded ring structure at pH 7. Group I may also have the structure: where one or two of the a, b, c, d, e, and f group is N, and the rest are C, and each S1-S6 independently is H or C1-C3 alkyl.

7230074, Jun 12, 2007

Feb 10, 2004

10/775598

William W. Bachovchin - Melrose MA, US
Andrew G. Plaut - Boston MA, US
George R. Flentke - Boston MA, US

Trustees of Tufts College - Medford MA

C07K 5/10

530330, 530327, 530328, 530329, 530331, 568 1, 548535, 514 15, 514 16, 514 17, 514 18

Peptide inhibitors of dipeptidyl-aminopeptidase type IV (DP-IV) are provided. The peptide inhibitors have an isomeric purity of about 96–99 percent. The peptide inhibitors include one or more amino acids covalently coupled to boroproline moiety. The compounds are useful as DP-IV inhibitors, in vivo and in vitro.

5462928, Oct 31, 1995

Jul 15, 1993

8/093302

William W. Bachovchin - Melrose MA
Andrew G. Plaut - Boston MA

New England Medical Center Hospitals, Inc. - Boston MA
Tufts University - Medford MA

A61K 3800, A61K 31675, A01N 5700, A01N 6500

514 19

The invention features an inhibitor of DP-IV, having the structure: ##STR1## wherein m is an integer between 0 and 10, inclusive; A and A' are L-amino acid residues such that the A in each repeating bracketed unit can be a different amino acid residue; the C bonded to B is in the L-configuration; the bonds between A and N, A' and C, and between A' and N are peptide bonds; and each X. sup. 1 and X. sup. 2 is, independently, a hydroxyl group or a group capable of being hydrolyzed to a hydroxyl group at physiological pH.