Inventors:
Andrew F. STEWART - Pittsburgh PA, US
International Classification:
A61K 38/29, C07K 14/635, C07H 21/04, C12N 15/63, C12N 5/10, C12N 7/01, C07K 16/26, A61K 39/395, A61K 31/7088, C12P 21/00, G01N 33/53, C12Q 1/68, A61K 35/76, G06G 7/58, A61P 21/00
US Classification:
4241331, 530399, 536 2351, 4353201, 435325, 4352351, 514 12, 5303892, 53038824, 5303873, 514 44 R, 435 694, 435 71, 435 6, 436501, 424 932, 703 11
Abstract:
The present invention relates to the use of mutants of parathyroid hormone-related protein, to treat disorders associated with smooth muscle cells, and to inhibit the cellular activation and proliferation thereof. The method can be employed in diverse tissues to effect therapeutic and prophylactic relief for disorders and diseases manifested by activation of smooth muscle that can lead to excessive smooth muscle proliferation. For example, where employed in the vasculature, the inventive method can be used to treat restenosis following angioplasty.