Inventors:
Christian P. Larsen - Atlanta GA, US
Thomas C. Pearson - Atlanta GA, US
Andrew B. Adams - Atlanta GA, US
Robert J. Peach - San Diego CA, US
Peter S. Linsley - Seattle WA, US
Joseph Roy Naemura - Bellevue WA, US
Jurgen Bajorath - Bonn, DE
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 38/16, C07K 14/705, C07K 16/46
US Classification:
514 12, 4241341, 530350, 5303873
Abstract:
The present invention is a method of inhibiting islet cell transplant rejection particular, to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of soluble CTLA4 mutant molecule is L104EA29YIg.