Inventors:
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX, US
Andrew A. Pieper - Iowa City IA, US
Joseph M. Ready - Carrollton TX, US
Jef K. De Brabander - Flower Mound TX, US
Assignee:
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - Austin TX
International Classification:
C07D 487/04, C07D 401/06, C07D 403/12, C07D 209/08, C07D 471/04, C07D 209/88, C07D 413/06
US Classification:
5142328, 514411, 514339, 514376, 514415, 514292, 514275, 514267
Abstract:
This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.