ANA COTRIM, DDS
Dentist in Bethesda, MD
License number
Maryland 78
Category
Dentist
Type
Dentist
License number
Maryland 78
Category
Dentist
Type
Oral and Maxillofacial Pathology
Address
Address
10 Center Dr, Bethesda, MD 20892
Phone
(301) 451-6303
Professional information
Ana Cotrim, Bethesda MD
Specialties:
Dentist
Address:
10 Center Dr, Bethesda, MD 20892
Methods Of Preventing The Development Of Mucositis And Related Disorders
US Patent:
2014006, Mar 6, 2014
Filed:
Mar 13, 2013
Appl. No.:
13/798863
Inventors:
The United States of America, as represented by the Secretary, Department of Health and Human Service - , US
Vyomesh Patel - Washington DC, US
Ana p. Cotrim - Bethesda MD, US
Alfredo Molinolo - Rockville MD, US
James B. Mitchell - Damascus MD, US
Vyomesh Patel - Washington DC, US
Ana p. Cotrim - Bethesda MD, US
Alfredo Molinolo - Rockville MD, US
James B. Mitchell - Damascus MD, US
International Classification:
A61K 31/436
US Classification:
514291
Abstract:
Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mTOR inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof.