Inventors:
Douglas Kim Graham - Aurora CO, US
Rachel Linger - Denver CO, US
Deborah Deryckere - Boulder CO, US
Susan Louise Sather - Denver CO, US
Amy Keating - Denver CO, US
Grace Kim - Aurora CO, US
Luis Brandao - Denver CO, US
International Classification:
A61K 39/395, A61P 35/00, C12N 5/09
Abstract:
The invention provides methods of treating neoplastic disorders in a mammal through the inhibition of Mer and/or AxI receptor tyrosine kinases as well as compounds and compositions useful for inhibiting these kinases in these methods. These treatment methods may be combined with the administration of one or more chemo therapeutic agent(s) to enhance the efficacy or minimize the toxicities of the chemotherapeutic agent(s).