Inventors:
Ammunje S. Nayak - Great Meadows NJ
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 922, A61K 924
Abstract:
An orally administrable sustained-release pharmaceutical tablet having at least two layers, which are directly compressible, is disclosed. The first layer, an immediate-release layer, contains an orally active analgesic and is readily susceptible to disintegration in the stomach. The second layer, a sustained-release layer which is directly compressed onto the first layer, comprises an orally active decongestant admixed with a major amount of a sustained-release agent so as to display increased resistance to disintegration and erosion in the gastro-intestinal tract relative to the first layer.