Inventors:
Amelia Bartholomew - Chicago IL, US
Eduardo Reina - Chicago IL, US
Alex Lyubimov - Chicago IL, US
Dan Cramer - Chicago IL, US
Assignee:
The Board of Trustees of the University of Illinois - Urbana
International Classification:
A61K 38/29, C07K 14/635, A61P 43/00, A61P 7/00, A61P 37/04
Abstract:
Currently there is no treatment for hematopoietic syndrome following radiation exposure. Exposed persons are presently treated with blood transfusions, growth factors such as G-CSF to promote neutrophil recovery. Present methods are targeted towards the bone marrow microenvironment, aiding in repair and regeneration with a decrease in the severity or possibly, complete avoidance of morbidity and mortality associated with the hematopoietic syndrome. Methods are useful for treatment of mass casualties following a radiation disaster.