DR. ALYSSA T FRANZEN, DMD
Dentist at Division St, Portland, OR
License number
Oregon D7605
Category
Dentist
Type
General Practice
Address
Address
12710 SE Division St, Portland, OR 97236
Phone
(503) 988-3410
Personal information
See more information about ALYSSA T FRANZEN at radaris.comName
Address
Phone
4320 SE Woodward St, Portland, OR 97206
3737 50Th Ave, Portland, OR 97221
Professional information
Alyssa T Franzen, Portland OR
Specialties:
Dentist
Address:
12710 Se Division St, Portland, OR 97236
Dr. Alyssa T Franzen, Portland OR - DMD (Doctor of Dental Medicine)
Specialties:
Dentistry
Address:
12710 SE Division St, Portland 97236
(503) 988-3410 (Phone)
(503) 988-3410 (Phone)
Languages:
English
Transfer Of Taxol From Yew Tree Cuttings Into A Culture Medium Over Time
US Patent:
5620875, Apr 15, 1997
Filed:
Feb 17, 1995
Appl. No.:
8/390125
Inventors:
Angela Hoffman - Beaverton OR
Courtney C. J. Voelker - Portland OR
Alyssa T. Franzen - Portland OR
Courtney C. J. Voelker - Portland OR
Alyssa T. Franzen - Portland OR
Assignee:
University of Portland - Portland OR
International Classification:
C12P 1702, C12P 100
US Classification:
435123
Abstract:
Taxol, an antineoplastic drug, has shown cytotoxic activity against numerous malignant tumors including: breast cancer, colon cancer, ovarian cancer, and skin cancer. Taxol is found in many species of yew including: slow-growing Taxus brevifolia and faster-growing Taxus media X Hicksii. Yew tree cuttings were cultured and the medium was extracted weekly, bi-weekly, and tri-weekly over a period of nine weeks. Taxol and other taxanes were separated through a multi-step procedure using hexane extractions, C-18 Sep Pak cartridges, and high performance liquid chromatography (HPLC). The concentration of the taxanes was then calculated. Taxol and other taxanes can continue to be transferred into a culture medium and extracted over a nine-week period. There is a higher yield when extracted weekly.