Inventors:
Bernhard Fleckenstein - Wiesenthau, DE
Jens Christian Albrecht - Fuerth, DE
Frank Neipel - Uttenreuth, DE
Alvin Friedman-Kien - New York NY, US
Yao Qi Huang - New York NY, US
Assignee:
New York University School of Medicine - New York NY
BehringDiagnostics GmbH - Marburg
International Classification:
C12P 21/06, C07K 1/00, C12N 5/00, C12N 15/00, C12N 15/63
US Classification:
435 691, 435 6952, 4353201, 435325, 435455, 4352521, 435471, 530300
Abstract:
The present invention relates to viral interleukin-6 (v-IL-6), which can be obtained by recombinant expression of the DNA of human herpesvirus type 8 (HHV-8), and which may be used in diagnosis and treatment of human diseases such as kaposi sarcoma, Castleman's disease, multiple myeloma, kidney cell carcinoma, mesangial proliferative glomerulonephritis or B cell lymphoma.