ALLEN LATHAM
Engineering in Boston, MA

4421503, Dec 20, 1983

Jul 9, 1981

6/281655

Allen Latham - Jamaica Plain MA
Donald W. Schoendorfer - Brookline MA

Haemonetics Corporation - Braintree MA

B04B 500

494 17

A pressure plate blood processing centrifuge apparatus is described. A plate is disposed adjacent a flexible bag in which blood is being processed. Under the influence of centrifugal force the plate, which is disposed inwardly nearer the center of rotation than the bag, expels a separated blood component from the bag into a receiver container. The container may be located (1) radially inward or (2) radially outward from the bag or (3) adjacent and equidistant from the center of rotation. In the embodiment in which the container is located radially outward from the bag, a valve is provided which is responsive to the specific density of separated components to stop the flow. In other embodiments, the mass of the plate is selected so as to expel only the desired component. A plurality of alternate embodiments are described which make the apparatus useful for a variety of apparatus, such as plasma pheresis, platelet pheresis and cell-washing.

4285464, Aug 25, 1981

Jun 2, 1980

6/155069

Allen Latham - Jamaica Plain MA

Haemonetics Corporation - Braintree MA

B04B 912, B04B 1102

233 26

Apparatus is disclosed for centrifugally separating blood into a first blood component, such as a plasma-rich component, and a second blood component, such as a plasma-poor component. This apparatus employs a self-balancing centrifuge intended to be used immediately adjacent to a blood donor. The blood pathway is completely disposable and includes a phlebotomy needle and blood compatible tubing connecting the phlebotomy needle to a flexible blood processing bag designed to be supported within a contoured processing chamber in the centrifuge rotor so that second blood component travels along a short internal bag dimension to achieve separation. A displacement chamber having a fluid operated diaphram is also positioned within the blood processing chamber of the centrifuge rotor. Separated first blood component can be expressed from the flexible blood bag by movement of the diaphram and collected in a receiver container as the centrifuge rotor spins. The centrifuge rotor can then be stopped to allow return of second blood component to the donor.

4303193, Dec 1, 1981

Jan 22, 1979

6/005126

Allen Latham - Jamaica Plain MA

Haemonetics Corporation - Braintree MA

B04B 914

233 23A

Apparatus is disclosed for centrifugally separating blood into a first blood component, such as a plasma-rich component, and a second blood component, such as a plasma-poor component. This apparatus employs a self-balancing centrifuge intended to be used immediately adjacent to a blood donor. The blood pathway is completely disposable and includes a phlebotomy needle and blood compatible tubing connecting the phlebotomy needle to a flexible blood processing bag designed to be supported within a contoured processing chamber in the centrifuge rotor so that second blood component travels along a short internal bag dimension to achieve separation. A displacement chamber having a fluid operated diaphram is also positioned within the blood processing chamber of the centrifuge rotor. Separated first blood component can be expressed from the flexible blood bag by movement of the diaphram and collected in a receiver container as the centrifuge rotor spins. The centrifuge rotor can then be stopped to allow return of second blood component to the donor.

4381776, May 3, 1983

Apr 14, 1981

6/254078

Allen Latham - Jamaica Plain MA

Haemonetics Corporation - Braintree MA

A61J 100, A61M 500

604317

An aseptically pure dispensing anticoagulant device adapted to be connected to a blood collection set and which may be aseptically treated by ethylene oxide or other high diffusivity sterilant without deleterious effects upon the anticoagulant. Various embodiments are shown; in one, a collapsible pouch is provided which includes a barrier against diffusion of water vapor and ethylene oxide. In another embodiment, a rigid anticoagulant container is employed which necessitates a secondary volume of air in a surrounding pouch to provide air to displace liquid in the rigid container as it passes into the set.

4086924, May 2, 1978

Oct 6, 1976

5/730106

Allen Latham - Jamaica Plain MA

Haemonetics Corporation - Natick MA

A61M 500, A61M 103

128214R

Plasmapheresis apparatus is disclosed which comprises a unique combination of blood withdrawal, separation and return means, together with automatic cycle control means. This apparatus can withdraw whole blood from a donor, separate it into plasma and non-plasma components, and return the non-plasma component to the donor while the donor remains connected to the apparatus throughout the entire procedure. Standard quantities of separated plasma can be obtained in significantly reduced times, and the possibility of mistakenly returning wrong blood components to the donor is eliminated.

4417884, Nov 29, 1983

Jul 9, 1981

6/281650

Donald W. Schoendorfer - Brookline MA
Allen Latham - Jamaica Plain MA

Haemonetics Corporation - Braintree MA

B04B 1100

494 4

A timing and control mechanism for a centrifuge comprising a piston to which is attached a cam having cam surfaces which interact with flexible tubing to control the rate of flow through the tubing. The velocity of the piston in the centrifugal force field is determined by the resistance to flow of fluid which the piston displaces. The movement of the cam is therefore a measure of the speed and duration of the centrifugal force.

5494592, Feb 27, 1996

Jan 13, 1995

8/372890

Allen Latham - Jamaica Plain MA
Glen E. Jorgensen - Marlborough MA
Theodoor H. S. Sibinga - Boston MA
Joseph R. Plante - Millis MA
Tracey E. Knapp - Hanover MA

Haemonetics Corporation - Braintree MA

A61M 3700, B01D 2126

210805

An apheresis apparatus and method is disclosed for increasing the purity and yield of platelets separated from donated whole blood in a centrifuge. The whole blood in the centrifuge is diluted by recirculating fluid, such as plasma or saline, at a first flow rate, to mix with further withdrawn whole blood prior to entering the centrifuge. As plasma is collected, it is recirculated through the centrifuge at a second flow rate to further improve the separation between the intermediate density components, i. e. , platelets and white blood cells in the "buffy coat. " The plasma is then recirculated through the centrifuge at a third flow rate and platelets are displaced out of the centrifuge while the plasma is recirculating through the centrifuge at the third flow rate.

4059108, Nov 22, 1977

Jul 15, 1975

5/596148

Allen Latham - Jamaica Plain MA

Haemonetics Corporation - Natick MA

A61M 500, B04B 1100

128214R

A pheresis process and apparatus for carrying it out. Blood from a donor is transferred to a pheresis bowl formed to have a red cell reservoir and a plasma reservoir in fluid communication through plasma ducts. The pheresis bowl is adapted for centrifuging to separate the red cells and plasma. This separation is accomplished simultaneously with the withdrawal of blood from the donor. At the end of the withdrawal the red cells are returned to the donor. The connection with the donor is thus continuously maintained during the entire procedure. The process is safe, fast and economical.

4204537, May 27, 1980

Jun 27, 1977

5/810213

Allen Latham - Jamaica Plain MA

Haemonetics Corporation - Braintree MA

A61M 500, A61J 100

128214R

A pheresis process and apparatus for carrying it out. Blood from a donor is transferred to a pheresis bowl formed to have a red cell reservoir and a plasma reservoir in fluid communication through plasma ducts. The pheresis bowl is adapted for centrifuging to separate the red cells and plasma. This separation is accomplished simultaneously with the withdrawal of blood from the donor. At the end of the withdrawal the red cells are returned to the donor. The connection with the donor is thus continuously maintained during the entire procedure. The process is safe, fast and economical.

4385630, May 31, 1983

Aug 29, 1980

6/182510

Ronald O. Gilcher - Edmond OK
Allen Latham - Jamaica Plain MA
Jonathan D. Schiff - Boston MA
Donald W. Schoendorfer - Brookline MA

Haemonetics Corporation - Braintree MA

A61M 500

604 31

A blood donation unit in which a reduced outside diameter phlebotomy needle is employed to minimize donor discomfort. The blood flow if, however, maintained at a flow level similar to that obtained with standard gauge phlebotomy needles by a roller pump which provides a predetermined pressure differential between the ends of the phlebotomy needle. The blood is mixed with a predetermined ratio of anticoagulant immediately after passing through the phlebotomy needle. The ratio of whole blood to anticoagulant is independent of the volume of whole blood collected.