Allen D Roses
Medical Practice in Durham, NC
License number
New Jersey 25MA02246800
Category
Medical Examiners
Type
Medical Doctor
Address
Address
Durham, NC
Personal information
See more information about Allen D Roses at radaris.comName
Address
Phone
10 Streamley Ct, Durham, NC 27705
53525 Bickett, Chapel Hill, NC 27517
10 Streamley Ct, Durham, NC 27705
315 Spruce St, Winston Salem, NC 27101
Professional information
See more information about Allen D Roses at trustoria.com
Presenilin-1 Gene Promoter
Presenilin-1 Gene Promoter
US Patent:
6255473, Jul 3, 2001
Filed:
Aug 29, 1997
Appl. No.:
8/920422
Inventors:
Michael P. Vitek - Apex NC
Noriaki Mitsuda - Durham NC
Allen D. Roses - Durham NC
Noriaki Mitsuda - Durham NC
Allen D. Roses - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C07H 2104, C12N 1500, C12N 1563, C12N 500
US Classification:
536 241
Abstract:
An isolated DNA molecule that directs neuron-specific transcription of a downstream heterologous DNA segment (a promoter segment) in a mammalian cell is disclosed. The isolated DNA molecule contains a promoter segment from the mouse genomic Presenilin-1 DNA, or a DNA sequence that hybridize to such DNA and directs neuron-specific transcription of a downstream heterologous DNA segment in a mammalian cell. DNA constructs comprising such promoter segments and various uses thereof are also disclosed.
Dr. Allen D Roses, Durham NC - MD (Doctor of Medicine)
Dr. Allen D Roses, Durham NC - MD (Doctor of Medicine)
Specialties:
Neuropsychiatry (Neurology)
Address:
1 Science Dr SUITE 342, Durham 27708
(919) 660-7699 (Phone), (919) 681-9289 (Fax)
(919) 660-7699 (Phone), (919) 681-9289 (Fax)
Certifications:
Neurology, 1973
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Perelman School of Medicine University of Pennsylvania
Graduated: 1967
Hospital Of The University Of Pennsylvania
Columbia-Presby Hosp
Duke University Hospital
Natl Ms Soc
Perelman School of Medicine University of Pennsylvania
Graduated: 1967
Hospital Of The University Of Pennsylvania
Columbia-Presby Hosp
Duke University Hospital
Natl Ms Soc
Method Of Binding Material To The .Beta.-Amyloid Peptide
Method Of Binding Material To The .Beta.-Amyloid Peptide
US Patent:
6294340, Sep 25, 2001
Filed:
Oct 21, 1996
Appl. No.:
8/734490
Inventors:
Warren J. Strittmatter - Durham NC
Allen D. Roses - Durham NC
David Huang - Durham NC
Dmitry Y. Goldgaber - Setauket NY
Allen D. Roses - Durham NC
David Huang - Durham NC
Dmitry Y. Goldgaber - Setauket NY
Assignee:
Duke University - Durham NC
International Classification:
G01N 3353, G01N 33543, G01N 33563
US Classification:
435 71
Abstract:
The present invention relates to the finding that antibodies bind to the. beta. -amyloid peptide, and that. beta. -amyloid peptide binds the hinge region of the immunoglobulin heavy chain, thereby preserving the ability of the immunoglobulin to bind antigen. Methods for binding compounds such as detectable groups to. beta. -amyloid peptide are accordingly presented.
Ppar-Gamma Agonists For Improvement Of Cognitive Function In Apoe4 Negative Patients
Ppar-Gamma Agonists For Improvement Of Cognitive Function In Apoe4 Negative Patients
US Patent:
2008026, Oct 23, 2008
Filed:
Sep 20, 2006
Appl. No.:
12/067374
Inventors:
Allen D Roses - Durham NC, US
Ann M. Saunders - Durham NC, US
Ann M. Saunders - Durham NC, US
International Classification:
A61K 31/425, A61K 31/44, A61P 25/00
US Classification:
514342, 514369
Abstract:
Disclosed is a method for improving cognitive function in a subject suffering from or susceptible to MCI, Alzheimer's disease or other dementias, which subject is not homozygous for the APOE4 allele, comprising the steps of:
Kit For Detecting The Apoe4 Allele, And For Diagnosing The Existence Or Risk Of Developing Alzheimer's Disease
Kit For Detecting The Apoe4 Allele, And For Diagnosing The Existence Or Risk Of Developing Alzheimer's Disease
US Patent:
5716828, Feb 10, 1998
Filed:
May 15, 1995
Appl. No.:
8/441001
Inventors:
Allen D. Roses - Durham NC
Warren J. Strittmatter - Durham NC
Guy S. Salvesen - Chapel Hill NC
Jan Enghild - Durham NC
Donald E. Schmechel - Durham NC
Warren J. Strittmatter - Durham NC
Guy S. Salvesen - Chapel Hill NC
Jan Enghild - Durham NC
Donald E. Schmechel - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C12Q 168, G01N 3353
US Classification:
435 6
Abstract:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
Creation Of Human Apolipoprotein E Isoform Specific Transgenic Mice In Apolipoprotein Deficient "Knockout" Mice
Creation Of Human Apolipoprotein E Isoform Specific Transgenic Mice In Apolipoprotein Deficient "Knockout" Mice
US Patent:
5767337, Jun 16, 1998
Filed:
Jul 31, 1995
Appl. No.:
8/509521
Inventors:
Allen D. Roses - Durham NC
John R. Gilbert - Durham NC
Donald E. Schmechel - Durham NC
John R. Gilbert - Durham NC
Donald E. Schmechel - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C12N 500, C12N 1500, C12N 1509, C12N 1563
US Classification:
800 2
Abstract:
A transgenic mouse that expresses the human Apo E isoforms Apo E2, Apo E3 or Apo E4 but is essentially incapable of expressing endogenous Apo E. Additionally, mice that express more than one of these isoforms are produced by selectively breeding the transgenic mice expressing the different Apo E isoforms disclosed herein. Thus, the present invention allows, among other things, the study of the effects of different combinations of human Apo E isoform expression on normal brain biology, development, function, aging and injury.
Methods Of Screening For Alzheimer's Disease
Methods Of Screening For Alzheimer's Disease
US Patent:
5508167, Apr 16, 1996
Filed:
Apr 13, 1994
Appl. No.:
8/227044
Inventors:
Allen D. Roses - Durham NC
Warren J. Strittmatter - Durham NC
Guy S. Salvesen - Chapel Hill NC
Jan Enghild - Durham NC
Donald E. Schmechel - Durham NC
Warren J. Strittmatter - Durham NC
Guy S. Salvesen - Chapel Hill NC
Jan Enghild - Durham NC
Donald E. Schmechel - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C12Q 168, C12Q 100, C12P 1934
US Classification:
435 6
Abstract:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA, encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
Apolipoprotein E Isoform-Specific Monoclonal Antibodies
Apolipoprotein E Isoform-Specific Monoclonal Antibodies
US Patent:
5767248, Jun 16, 1998
Filed:
Apr 8, 1997
Appl. No.:
8/835503
Inventors:
Allen D. Roses - Durham NC
Warren J. Strittmatter - Durham NC
Guy S. Salvesen - Chapel Hill NC
Jan Enghild - Durham NC
Donald E. Schmechel - Durham NC
Warren J. Strittmatter - Durham NC
Guy S. Salvesen - Chapel Hill NC
Jan Enghild - Durham NC
Donald E. Schmechel - Durham NC
Assignee:
Duke University - Durham NC
International Classification:
C07K 1600
US Classification:
53038825
Abstract:
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
Iterative Analysis Of Non-Responding Population In The Design Of Pharmacogenetic Studies
Iterative Analysis Of Non-Responding Population In The Design Of Pharmacogenetic Studies
US Patent:
2004003, Feb 26, 2004
Filed:
Sep 10, 2003
Appl. No.:
10/659946
Inventors:
Allen Roses - Durham NC, US
International Classification:
G06F017/50
US Classification:
703/001000
Abstract:
A method of designing human clinical drug trials in which the drug under study is administered to a defined population of test patients who have demonstrated a predisposition to responding to the study drug by virtue of their having one or more genes that have independently been determined to be associated with the desired response.
Iterative Analysis Of Non-Responding Population In The Design Of Pharmacogenetic Studies
Iterative Analysis Of Non-Responding Population In The Design Of Pharmacogenetic Studies
US Patent:
2001004, Dec 6, 2001
Filed:
Apr 5, 2001
Appl. No.:
09/826629
Inventors:
Allen Roses - Durham NC, US
International Classification:
G01N033/48, G01N031/00, G01N037/00, A01N043/04, A01N061/00
US Classification:
702/019000, 514/002000, 514/044000, 702/022000, 702/082000, 702/083000
Abstract:
A method of designing human clinical drug trials in which the drug under study is administered to a defined population of test patients who have demonstrated a predisposition to responding to the study drug by virtue of their having one or more genes that have independently been determined to be associated with the desired response.