Inventors:
Allan M. Chin - Palo Alto CA
Assignee:
Applied Biosystems, Inc. - Foster City CA
International Classification:
G01N 2726, B01D 5702
Abstract:
A method of fractionating nucleic acid fragments is disclosed. The method is based on counter migration of the fragments in an upstream direction through a polymer solution which is moving by electroosmotic flow in a downstream direction. Fractionation of selected-size nucleic acid fragments can be enhanced by reducing the difference between the electroosmotic flow rate and the migration rates of the selected-size fragments.