Inventors:
Olaf Schneewind - Chicago IL, US
Alice G. Cheng - Boston MA, US
Dominique M. Missiakas - Chicago IL, US
Hwan Keun Kim - Naperville IL, US
Hye-Young Kim - Rancho Cucamonga CA, US
Assignee:
The University of Chicago - Chicago IL
International Classification:
A61K 39/085
Abstract:
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant. In some embodiments, the methods and compositions involve SdrD, ClfA, and/or FnbpB polypeptides.