ALFRED LEWIS GEORGE JR
Medical Practice in Brentwood, TN
License number
Pennsylvania MD038244E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Brentwood, TN 37027
Pennsylvania
Pennsylvania
Personal information
See more information about ALFRED LEWIS GEORGE JR at radaris.comName
Address
Phone
908 Penn St, Brackenridge, PA 15014
679 Pike Rd, Johnstown, PA 15909
142 Churchville Ln, Southampton, PA 18966
138 Churchville Ln, Southampton, PA 18966
1129 N 12Th St, Reading, PA 19604
Professional information
Ranolazine For The Treatment Of Cns Disorders
US Patent:
2010029, Nov 18, 2010
Filed:
May 13, 2010
Appl. No.:
12/779753
Inventors:
Luiz Belardinelli - Palo Alto CA, US
Alfred George - Brentwood TN, US
Kristopher Kahlig - Nashville TN, US
Sridharan Rajamani - Fremont CA, US
Alfred George - Brentwood TN, US
Kristopher Kahlig - Nashville TN, US
Sridharan Rajamani - Fremont CA, US
Assignee:
Gilead Palo Alto, Inc. - Foster City CA
International Classification:
A61K 31/55, A61K 31/495, A61K 31/53, A61K 31/5513, A61P 25/08, A61P 25/06, A61P 25/00
US Classification:
514217, 51425212, 514242, 514221
Abstract:
The present invention relates to a method for CNS disorders such as epilepsy and migraine comprising the administration of a therapeutically effective amount of ranolazine.
Purified And Isolated Potassium-Chloride Cotransporter Nucleic Acids And Polypeptides And Therapeutic And Screening Methods Using Same
US Patent:
2003002, Feb 6, 2003
Filed:
Apr 16, 2001
Appl. No.:
09/835976
Inventors:
David Mount - Brentwood TN, US
Eric Delpire - Nashville TN, US
Gerardo Gamba - Mexico City, MX
Alfred George - Brentwood TN, US
Eric Delpire - Nashville TN, US
Gerardo Gamba - Mexico City, MX
Alfred George - Brentwood TN, US
International Classification:
C07K001/00, C07K014/00, C07K017/00
US Classification:
530/350000
Abstract:
KCC2, KCC3 and KCC4 potassium-chloride cotransporter proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to KCC2, KCC3 and KCC4 homologs, and methods of producing the same, are also disclosed. KCC2, KCC3 and KCC4 gene products have biological activity in potassium-chloride cotransport. Thus, therapeutic methods involving this activity are also disclosed.
Purified And Isolated Potassium-Chloride Cotransporter Nucleic Acids And Polypeptides And Therapeutic And Screening Methods Using Same
US Patent:
2007020, Sep 6, 2007
Filed:
Dec 12, 2006
Appl. No.:
11/637625
Inventors:
David Mount - Brentwood TN, US
Eric Delpire - Nashville TN, US
Gerardo Gamba - Mexico City, MX
Alfred George - Brentwood TN, US
Eric Delpire - Nashville TN, US
Gerardo Gamba - Mexico City, MX
Alfred George - Brentwood TN, US
Assignee:
Vanderbilt University - Nashville TN
International Classification:
A61K 39/395, A61K 38/16, C07K 14/00, C07K 16/18, C12N 5/06, G01N 33/53
US Classification:
424130100, 435346000, 435007100, 514012000, 530350000, 530387100
Abstract:
KCC2, KCC3, and KCC4 potassium-chloride cotransporter proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to KCC2, KCC3, and KCC4 homologs, and methods of producing the same, are also disclosed. KCC2, KCC3, and KCC4 gene products have biological activity in potassium-chloride cotransport. Thus, therapeutic methods involving this activity are also disclosed.
Method Of Screening For Susceptibility To Drug-Induced Cardiac Arrhythmia
US Patent:
2003010, Jun 12, 2003
Filed:
Sep 30, 2002
Appl. No.:
10/260861
Inventors:
Alfred George - Brentwood TN, US
Dan Roden - Nashville TN, US
Dan Roden - Nashville TN, US
International Classification:
C12Q001/68, C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
Isolated polynucleotide molecules, and peptides encoded by these molecules, are used in the analysis of human cardiac potassium channel minK subunit variants, as well as in screening and diagnostic applications relating to a D85N polymorphism in the KCNE1 gene encoding the human cardiac potassium channel minK subunit polypeptide. By analyzing biological samples from a subject, it is possible to type a human cardiac potassium channel minK subunit with regard to the KCNE1-D85N polymorphism, for example, in the context of screening for susceptibility to drug-induced cardiac arrhythmias.
Expression System For Human Brain-Specific Voltage-Gated Sodium Channel, Type 1
US Patent:
2005026, Nov 24, 2005
Filed:
Feb 25, 2003
Appl. No.:
10/374954
Inventors:
Alfred George - Brentwood TN, US
Christoph Lossin - Nashville TN, US
Christoph Lossin - Nashville TN, US
International Classification:
C12Q001/68, C07H021/04, C12N009/00, C12P021/02, C12N005/06
US Classification:
435006000, 435069100, 435183000, 435320100, 435325000, 536023200
Abstract:
Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A polypeptides, assay methods employing the same, and methods and compositions for modulation of sodium channel function.
Human Kcr1 Regulation Of Herg Potassium Channel Block
US Patent:
2003001, Jan 16, 2003
Filed:
Oct 30, 2001
Appl. No.:
10/000151
Inventors:
Jeffrey Balser - Brentwood TN, US
Alfred George - Brentwood TN, US
Dan Roden - Nashville TN, US
Alfred George - Brentwood TN, US
Dan Roden - Nashville TN, US
International Classification:
G01N033/567, C12Q001/68, C12P021/02, C12N005/06, C12N015/85
US Classification:
435/007210, 435/006000, 435/455000, 435/325000
Abstract:
The present invention discloses methods relating to screening methods and methods of identifying a compound that can modulate HERG potassium channel activity. The methods generally employ at least HERG and KCR1 polypeptides. The disclosed methods can be applied in the development of a candidate pharmaceutical or they can be employed to evaluate presently marketed pharmaceuticals.