ALFRED JAMES LEWY, MD
Psychiatric at Sam Jackson Park Rd, Portland, OR

6423738, Jul 23, 2002

May 30, 2000

09/580075

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

Oregon Health Sciences University - Portland OH

A61K 3140

514415, 514416, 514418, 514419, 548491, 548494, 548495, 548496

A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined with relation to the time of dim light endogenous melatonin onset. Embodiments capable of alleviating the effects of jet lag, winter depression and shift-work sleep disturbance are provided.

2008005, Mar 6, 2008

Jul 31, 2007

11/831544

Alfred Lewy - Portland OR, US

OREGON HEALTH & SCIENCE UNIVERSITY - Portland OR

A61K 31/4045, A61P 43/00

514415000

A method for achieving a chronobiologic effect on a circadian rhythm in a human infant or fetus in utero is described. The method involves the administration of melatonin or dose-equivalent melatonin analogue or melatonin receptor agonist to an infant by administering melatonin or dose-equivalent melatonin precursor, melatonin analogue or melatonin receptor agonist to the infant's breast-feeding mother or wet nurse, and to a fetus by administration of melatonin or dose-equivalent melatonin precursor, melatonin analogue or melatonin receptor agonist to the pregnant woman. Alternatives wherein melatonin or dose-equivalent melatonin analogue or melatonin receptor agonist is administered directly to the infant, such as in formula or in expressed breast milk, are also provided.

4654361, Mar 31, 1987

Jan 27, 1986

6/822438

John R. Samples - Portland OR
Alfred J. Lewy - Portland OR

State of Oregon, acting by and through the Oregon State Board of Higher
Education, acting for and on behalf of the Oregon Health Sciences
University - Portland OR

A61K 3140

514419

A method of lowering the intraocular pressure in a human having abnormally high intraocular pressure, comprising administering systemically thereto an amount of melatonin effective to lower the intraocular pressure.

5591768, Jan 7, 1997

Aug 24, 1993

8/110878

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

State of Oregan, Acting by and Through the Oregon State Board of Higher
Education on Behalf of the Oregon Health Sciences University - Portland OR

A61K 3140, A61K 31405

514415

A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined with relation to the time of dim light endogenous melatonin onset. Embodiments capable of alleviating the effects of jet lag, winter depression and shift-work sleep disturbance are provided.

5716978, Feb 10, 1998

May 30, 1995

8/454545

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

State of Oregon - Portland OR

A61K 3140

514415

A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin from about 6 hours to about 19 hours prior to when the normal sleep phase should begin, depending on whether a phase advance shift in circadian rhythms or a phase delay shift is desired. This is typically from about 4 hours to about 17 hours prior to the time of endogenous melatonin onset.

5420152, May 30, 1995

Jun 15, 1993

8/077426

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR

State of Oregon, Acting by and Through the Oregon State Board of Higher
Education on Behalf of the Oregon Health Sciences University, a
non-profit organization - Portland OR

A61K 3140

514419

A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin from about 6 hours to about 19 hours prior to when the normal sleep phase should begin, depending on whether a phase advance shift in circadian rhythms or a phase delay shift is desired. This is typically from about 4 hours to about 17 hours prior to the time of endogenous melatonin onset.

2006016, Jul 27, 2006

Sep 21, 2004

10/945843

Alfred Lewy - Portland OR, US
Robert Sack - Portland OR, US

A61K 9/22, A61K 31/405

424468000, 514419000

A method for treating circadian rhythm phase disorders is described. The invention provides methods to specifically advance or delay the phase of certain circadian rhythms in humans. The disclosed methods relate to the administration of melatonin at times determined with relation to the time of dim light endogenous melatonin onset. Embodiments capable of alleviating the effects of jet lag, winter depression and shift-work sleep disturbance are,provided.

5707652, Jan 13, 1998

Jun 7, 1995

8/480558

Alfred J. Lewy - Portland OR
Robert L. Sack - Portland OR
Keith A. Parrott - Corvallis OR
James W. Ayres - Corvallis OR

State of Oregon - Portland OR

A61K 952, A61K 954, A61K 922, A61K 926

424457

Methods for treating circadian rhythm disorders and sleep disorders are described. The method involves oral administration of a sustained release composition of melatonin to produce a normal melatonin pattern when the normal pattern has been disrupted or is missing.