ALEXANDER SASHA KRUPNICK
Medical Practice in Philadelphia, PA
License number
Pennsylvania MD067605L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Philadelphia, PA 19146
Personal information
See more information about ALEXANDER SASHA KRUPNICK at radaris.comName
Address
Phone
2412 Naudain St, Philadelphia, PA 19146
2412 Naudain St, Philadelphia, PA 19146
Professional information
Cell Delivery Patch For Myocardial Tissue Engineering
US Patent:
7396537, Jul 8, 2008
Filed:
Feb 28, 2003
Appl. No.:
10/378015
Inventors:
Alexander Krupnick - Philadelphia PA, US
Daniel Kreisel - Philadelphia PA, US
Bruce R. Rosengard - Gladwyne PA, US
Daniel Kreisel - Philadelphia PA, US
Bruce R. Rosengard - Gladwyne PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 9/00
US Classification:
424400, 424443, 424444, 424 931
Abstract:
A patch for cardiac tissue engineering includes a gel layer supported by an intermediate layer, which is attached to a reinforcement layer. These patches may be implanted in a heart to treat pediatric congenital malformations of the heart as well as adult ischemic myopathies. The gel layer may include cells such as, for example, stem cells; the intermediate layer may be biodegradable porous mesh and the reinforcement layer may be polytetrafluoroethylene. Included are methods for making patches according to the invention and for tissue engineering using patches of the invention.
Enginerred Bone Marrow
US Patent:
2003012, Jul 10, 2003
Filed:
Oct 25, 2002
Appl. No.:
10/280056
Inventors:
Alan Flake - Bryn Mawr PA, US
Alexander Krupnick - Philadelphia PA, US
Alexander Krupnick - Philadelphia PA, US
Assignee:
Children's Hospital of Philadelphia
International Classification:
C12N005/08
US Classification:
435/372000
Abstract:
An engineered bone marrow composition, preferably comprising bone marrow cells, pulverized bone, and type 1 collagen, can be transplanted into the portal system of a patient. The engineered bone marrow provides a microenvironment, for engraftment of hematopoietic stem cells, that increases levels of chimerism while decreasing or eliminating failure of engraftment.
Engineered Bone Marrow
US Patent:
2006013, Jun 22, 2006
Filed:
Dec 28, 2005
Appl. No.:
11/319353
Inventors:
Alan Flake - Bryn Mawr PA, US
Alexander Krupnick - Philadelphia PA, US
Alexander Krupnick - Philadelphia PA, US
International Classification:
C12N 5/08, A61K 35/32
US Classification:
424549000, 435372000
Abstract:
An engineered bone marrow composition, preferably comprising bone marrow cells, pulverized bone, and type 1 collagen, can be transplanted into the portal system of a patient. The engineered bone marrow provides a microenvironment, for engraftment of hematopoietic stem cells, that increases levels of chimerism while decreasing or eliminating failure of engraftment.