ALEXANDER DUNCAN, MD
Osteopathic Medicine at Clifton Rd, Atlanta, GA

5297234, Mar 22, 1994

May 9, 1990

7/521185

Frank H. Harms - Marietta GA
John R. Beard - Memphis TN
Alexander Duncan - Dunwoody GA

LifeSource Advanced Blood Bank Systems, Inc. - Atlanta GA

A61F 700

392470

The temperature of bags of blood or blood components is varied by directing a heated or refrigerated flow of air through vents (138) of pairs of opposing ducts (130A, 130B) longitudinally spaced across gaps to present thermal processing chambers (136) into which the bags are received. The vents are centrally located on vertical tubes (132) laterally separated by vertical air return slots (135), and act to direct the airflow substantially perpendicular and with turbulence against the bags. In a described thermal processing unit (110), the spacings of the vents and tubes are chosen to match the corresponding spacing of vertical tubular chambers (62) of a preferred bag (10) with which the unit (110) can be used. A central system automatically regulates airflow temperature in accordance with bag internal core temperature measurements taken externally of the bags by a sensor (140) having a sensing tip (142) that is pressed inwardly into bag flexible sheet material (11, 12) when airflow is present, and retracted when airflow is stopped.

5250294, Oct 5, 1993

Nov 17, 1992

7/977530

Robert L. Hunter - Tucker GA
Alexander Duncan - Dunwoody GA

Emory University - Atlanta GA

A61K 31745

424 7831

In accordance with the present invention, a composition and method is provided for perfusion of organs. The present invention includes perfusion of organs in situ and before transplantation. The method comprises perfusing an organ with a perfusion medium containing an effective amount of a surface active copolymer. The surface active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C. sub. 2 H. sub. 4 O). sub. b (C. sub. 3 H. sub. 6 O). sub. a (C. sub. 2 H. sub. 4 O). sub. b H wherein a is an integer such that the hydrophobe represented by (C. sub. 3 H. sub. 6 O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C. sub. 2 H. sub. 4 O) constitutes approximately 50% to 90% by weight of the compound.

5648071, Jul 15, 1997

Mar 24, 1995

8/409549

Robert L. Hunter - Tucker GA
Alexander Duncan - Dunwoody GA

Emory University - Atlanta GA

A61K 3174

424 7831

In accordance with the present invention, a method is provided for treating tumors. More particularly, the present invention relates to a method for treating tumors comprising injecting a solution of certain ethylene oxide-propylene oxide surface-active copolymers and a solution containing chemotherapeutic agents into a human or animal with a tumor. The solutions can be injected simultaneously or separately at different times. In addition, the surface-active copolymer and the chemotherapeutic agent can be in the same solution. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C. sub. 2 H. sub. 4 O). sub. b (C. sub. 3 H. sub. 6 O). sub. a (O. sub. 2 H. sub. 4 O). sub. b H wherein a is an integer such that the hydrophobe represented by (C. sub. 3 H. sub. 6 O) has a molecular weight of approximately 950 to 4000 daltons, preferably approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C. sub. 2 H. sub.

5064643, Nov 12, 1991

Jul 25, 1990

7/560010

Robert L. Hunter - Tucker GA
Alexander Duncan - Dunwoody GA

Emory University - Atlanta GA

A61K 31745, A61K 31725

424 83

In accordance with the present invention, a method is provided for treating sickle cell anemia. The method comprises injecting an effective concentration of a surface active copolymer into the patient with sickle cell anemia. The surface active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C. sub. 2 H. sub. 4 O). sub. b (C. sub. 3 H. sub. 6 O). sub. a (C. sub. 2 H. sub. 4 O). sub. b H wherein a is an integer such that the hydrophobe represented by (C. sub. 3 H. sub. 6 O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C. sub. 2 H. sub. 4 O) constitutes approximately 50% to 90% by weight of the compound.

5240702, Aug 31, 1993

Dec 4, 1992

7/985746

Robert L. Hunter - Tucker GA
Alexander Duncan - Dunwoody GA

Emory University - Atlanta GA

A61K 31745

424 7831

In accordance with the present invention, a method is provided for treating stroke. More particularly, the present invention relates to a method for treating stroke comprising injecting a non-emulsion, homogeneous solution of certain ethylene oxide-propylene oxide condensation surface-active copolymers. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C. sub. 2 H. sub. 4 O). sub. b (C. sub. 3 H. sub. 6 O). sub. a (C. sub. 2 H. sub. 4 O). sub. b H wherein a is an integer such that the hydrophobe represented by (C. sub. 3 H. sub. 6 O) has a molecular weight of approximately 950 to 4000 daltons, preferably approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C. sub. 2 H. sub. 4 O) constitutes approximately 50% to 90% by weight of the compound.

4837014, Jun 6, 1989

Jan 13, 1989

7/297156

Robert L. Hunter - Tucker GA
Alexander Duncan - Dunwoody GA

Emory University - Atlanta GA

A61K 3174, A61K 3754, A61K 37547

424 78

In accordance with the present invention, a method is provided that is effective in treating sickle cell anemia. The method comprises a method of treating a person with sickle cell disease comprising the step of injecting into the person with sickle cell disease a solution with an effective concentration of a surface active copolymer of the following formula: HO(C. sub. 2 H. sub. 4 O). sub. b (C. sub. 3 H. sub. 6 O). sub. a (C. sub. 2 H. sub. 4 O). sub. b H wherein a is an integer such that the hydrophobe represented by (C. sub. 3 H. sub. 6 O) has a molecular weight of approximately 950 to 4000 and b is an integer such that the hydrophile portion represented by (C. sub. 2 H. sub. 4 O) constitutes approximately 50% to 90% by weight of the compound.

5080894, Jan 14, 1992

May 17, 1990

7/525111

Robert L. Hunter - Tucker GA
Alexander Duncan - Dunwoody GA

Emory University - Atlanta GA

A61K 31745, A61K 3750

424 7838

In accordance with the present invention, a method and composition is provided for treating an animal or human with ischemic tissue. The method comprises injecting an effective amount of a free-radical scavenger and a surface-active copolymer into an animal or human with damaged tissue. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: ##STR1## wherein a is an interger such that the hydrophobe represented by (C. sub. 3 H. sub. 6 O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C. sub. 2 H. sub. 4 O) constitutes approximately 50% to 90% by weight of the compound.

4801452, Jan 31, 1989

May 7, 1987

7/045459

Robert L. Hunter - Tucker GA
Alexander Duncan - Dunwoody GA

A61K 3754, A61K 37547, A61K 3750, A61K 3774

424 9463

In accordance with the present invention, a composition is provided that is effective in dissolving blood clots and reestablishing and maintaining blood flow through thrombosed coronary or other blood vessels. The fibrinolytic composition of the present invention comprises an enzyme, such as streptokinase, urokinase, tissue plasminogen activator or other fibrinolytic enzyme, and a surface-active copolymer. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C. sub. 2 H. sub. 4 O). sub. b (C. sub. 3 H. sub. 6 O). sub. a (C. sub. 2 H. sub. 4 O). sub. b H wherein a is an integer such that the hydrophobe represented by (C. sub. 3 H. sub. 6 O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C. sub. 2 H. sub. 4 O) constitutes approximately 50% to 90% by weight of the compound.

5240701, Aug 31, 1993

Jan 29, 1992

7/827640

Robert L. Hunter - Tucker GA
Alexander Duncan - Dunwoody GA

Emory University - Atlanta GA

A61K 31745, A61K 31725, A61M 3100

424 7831

In accordance with the present invention, a method is provided for improving angioplasty procedures by reducing tissue damage during the procedure comprising infusing a non-emulsion, homogeneous solution of certain ethylene oxide-propylene oxide surface-active copolymers before, during and/or after the angioplasty procedure. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C. sub. 2 H. sub. 4 O). sub. b (C. sub. 3 H. sub. 6 O). sub. a (C. sub. 2 H. sub. 4 O). sub. b H wherein a is an integer such that the hydrophobe represented by (C. sub. 3 H. sub. 6 O) has a molecular weight of approximately 950 to 4000 daltons, preferably approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C. sub. 2 H. sub. 4 O) constitutes approximately 50% to 90% by weight of the compound.