Inventors:
Alexander B. Niculescu - Indianapolis IN, US
John I. Nurnberger - Indianapolis IN, US
Daniel R. Salomon - San Diego CA, US
Assignee:
THE SCRIPPS RESEARCH INSTITUTE - La Jolla CA
International Classification:
C40B 30/00, G01N 33/68, C12Q 1/48, C12Q 1/44, C12Q 1/42, C12Q 1/02, C12Q 1/68, G01N 33/53
US Classification:
506 7, 436 86, 436 87, 435 15, 435 19, 435 21, 435 29, 435 6, 435 792
Abstract:
A plurality of markers determine the diagnosis of a mood disorder based on their expression in a sample such as blood. Subsets of biomarkers predict the diagnosis of high or low mood disorders. The biomarkers are identified using a convergent functional genomics approach based on animal and human data. Methods and compositions for clinical diagnosis of mood disorders are provided.