Inventors:
Robin Shandas - Boulder CO, US
Christopher M. Yakacki - Atlanta GA, US
Kenneth Gall - Atlanta GA, US
Alex E. Eckstein - Centennial CO, US
Michael Lyons - Boulder CO, US
Devatha P. Nair - Lakewood CO, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO - Denver CO
International Classification:
A61F 2/92, A61M 29/00, A61M 29/04, B29C 35/02
US Classification:
623 119, 623 118, 606198, 606194, 264494
Abstract:
Medical devices for in vivo medical applications are disclosed. The medical devices are constructed of shape memory polymer (SMP) materials capable of assuming a memory shape at physiological temperatures. These medical devices may be used in surgical procedures and in both vascular and non-vascular applications. These SMP medical devices have a post-implantation memory shape that is substantially identical to or slightly larger than the insertion site to adapt to vessel growth or size changes. SMP medical devices may be formed as stents or occlusion devices (i.e., plugs) having a number of different structural features. The SMP medical devices may be formed from a first monomer and a second cross-linking monomer, wherein the weight percentages of the first and second monomers are selected by performing an iterative function to reach a predetermined glass transition temperature (T) and a predetermined rubbery modulus to optimize post-implantation memory shape properties of the devices.