ALBERT T LEUNG, M.D.
Osteopathic Medicine at Tanager Dr, East Amwell Township, NJ
License number
New Jersey 76156
Category
Osteopathic Medicine
Type
Endocrinology, Diabetes & Metabolism
License number
New Jersey MA67883
Category
Osteopathic Medicine
Type
Endocrinology, Diabetes & Metabolism
Address
Address
7 Tanager Dr, East Amwell Township, NJ 08551
Phone
(732) 406-6315
Professional information
Liquid Bisphosphonate Formulations For Bone Disorders
US Patent:
2003013, Jul 24, 2003
Filed:
Nov 26, 2002
Appl. No.:
10/305868
Inventors:
Anastasia Daifotis - Westfield NJ, US
Albert Leung - Ringoes NJ, US
Andrew Denker - Hoboken NJ, US
Paul Bergquist - Collegeville PA, US
Albert Leung - Ringoes NJ, US
Andrew Denker - Hoboken NJ, US
Paul Bergquist - Collegeville PA, US
International Classification:
A61K031/675, A61K031/663
US Classification:
514/089000, 514/102000
Abstract:
The present invention relates to high dose oral liquid formulations of bisphosphonate and their methods of use to treat/prevent diseases related to bone remodeling or bone disorders, such as for example, Paget's disease, osteoporosis, metastatic bone disease, hypercalcemia of malignancy, periprosthetic osteolysis, periodontal disease, arthritic conditions, and the like, while minimizing the potential for esophageal irritation and other adverse gastrointestinal effects. These methods comprise orally administering to a mammal in need thereof a pharmaceutically effective amount of the liquid pharmaceutical composition of at least one bisphosphonate, or a pharmaceutically acceptable salt thereof, as a unit dosage according to a continuous schedule having a once-weekly, twice-weekly, biweekly, twice-monthly, or monthly dosing interval. The present invention also relates to liquid pharmaceutical compositions of the bisphosphonate for carrying out these methods.