ALBERT MONTGOMERY KLIGMAN
Medical Practice in Philadelphia, PA

4603146, Jul 29, 1986

Jul 26, 1985

6/759505

Albert M. Kligman - Philadelphia PA

A61K 3120

514559

Various effects of aging of skin due to impairment of differentiation of epidermal epithelial cells and loss of collagen fibers, abnormal changes in elastic fibers and deterioration of small blood vessels in the dermis of the skin are retarded by applying topically to the epidermis in a maintenance therapy program effective amounts of vitamin A acid (tretinoin) such that epithelial growths are substantially reduced and prevented and the skin substantially regains and maintains its firmness, turgor and elasticity. Moreover, with persistent treatment dermal blood cells and vessels increase and the epidermis and dermis thicken, resulting in improved ability of the skin to sense, resist and recover from irritation or injury. Further, hyperpigmentation, lines and wrinkles due to aging are reduced and prevented. The treatment is particularly useful for human facial skin and preferably applied in amounts insufficient to cause excessive irritation.

6008254, Dec 28, 1999

May 1, 1998

9/071017

Douglas E. Kligman - Philadelphia PA
Albert M. Kligman - Philadelphia PA

A61K 3119, A61K 3107

514570

Various skin disorders, excluding acne are treated by topical application to the skin of a tretinoin-containing composition including tretinoin in a dermatologically acceptable vehicle at such a concentration and applied in such a way as to induce desquamation of the skin to ameliorate the disorder. Preferably the compositions contain greater than 0. 1 weight percent tretinoin, and more preferably at least 0. 2 weight percent. The vehicle is preferably a solvent for the tretinoin, such as an alcohol/glycol or hydroalcoholic vehicle, but it is also possible to apply the tretinoin in a non-solvent vehicle such as emulsifying or suspending the tretinoin in a cream, dressing, gel, ointment or liquid polymer. The treatment achieves rapid amelioration of skin disorders such as photodamaged skin, hyperpigmentation, rosacea, premalignant cancers, wrinkles, superficial scarring, epidermal atrophy and atypia, and keratosis pilaris by daily or every other day application for about one to two months. Thereafter, the high strength applications may be tapered and the treated skin maintained with more conventional lower concentration compositions.

4318907, Mar 9, 1982

Apr 4, 1978

5/893239

Albert M. Kligman - Philadelphia PA
Walter L. McKenzie - Williamsville NY
Peter F. Ciesla - Lancaster NY

Westwood Pharmaceuticals, Inc. - Buffalo NY

A61K 31075, A61K 3160

424230

Procedure for treating acne vulgaris that uses salicylic acid and benzoyl peroxide either sequentially or simultaneously. Compositions for practicing each of these aspects of the invention are also described.

5998395, Dec 7, 1999

Sep 10, 1993

8/119510

Albert M. Kligman - Philadelphia PA

A61K 3156, A61K 3120

514171

Inflammatory dermatoses are controlled and cleared by topical application to the affected areas of the skin of a composition containing both a corticosteroid and a retinoid. The combined therapy is more effective than either active ingredient alone and is particularly effective for chronic dermatoses which are or have become resistant to corticosteroid treatment alone. After clearing has been obtained with once or twice daily applications of the corticosteroid-retinoid composition, usually after several weeks, clearance can be maintained by less frequent application or lower concentrations of the composition or by application of only one of the corticosteroid or retinoid, less potent corticosteroids, or other non-steroidal therapies, depending upon the particular dermatosis being treated.

5134163, Jul 28, 1992

Sep 1, 1989

7/402271

Albert M. Kligman - Philadelphia PA

A61K 3120

514559

Straie distensae lesions may be prevented and/or reduced in size by topically applying to the skin affected with the lesions an effective amount of retinoic acid, preferably by daily application in a dermatologically acceptable vehicle, such as a cream base, at a concentration of about 0. 025 to 0. 1 weight percent. When applied during the straie rubrae stage, the retinoic acid may be effective to prevent the formation of straie albae lesions, and when applied in either stage, the retinoic acid may be effective to reduce the width and depth of the lesions, with improved texture and softness.

5468495, Nov 21, 1995

Mar 6, 1992

7/836320

Albert M. Kligman - Philadelphia PA

A61K 700, A61K 3107

424401

Striae distensae lesions may be prevented and/or reduced in size by topically applying to the skin affected with the lesions an effective amount of a retinoid, preferably retinoic acid, preferably by daily application in a dermatologically acceptable vehicle, such as a cream base, at a concentration of about 0. 025 to 0. 1 weight percent retinoic acid. When applied during the striae rubrae stage, the retinoid may be effective to prevent the formation of striae albae lesions, and when applied in either stage, the retinoid may be effective to reduce the width and depth of the lesions, with improved texture and softness.

4752472, Jun 21, 1988

Mar 25, 1986

6/843738

Albert M. Kligman - Philadelphia PA

Exovir, Inc. - Great Neck NY

A61K 3178

424 81

A method for the cosmetic treatment of human skin, particularly facial skin, for the removal of materials from the surface and the sebaceous follicles is disclosed. The method comprises applying a layer of liquid polymerizable adhesive to the skin, then applying a pliable adhesive tape to cover the applied liquid adhesive and allowing the polymerization of said layer of polymerizable adhesive to take place and then removing the layer of polymerized adhesive from the skin by stripping the tape from the skin. In this treatment the materials on the surface of the skin and within the sebaceous follicles being attached to and removed with the layer of polymerized adhesive along with the tape. Alpha-cyanoacrylate is usefully employed as the polymerizable adhesive in this treatment.

4355028, Oct 19, 1982

Apr 30, 1981

6/259327

Albert M. Kligman - Philadelphia PA
Walter L. McKenzie - Williamsville NY
Peter F. Ciesla - Lancaster NY

Westwood Pharmaceuticals, Inc. - Buffalo NY

A61K 3160, A61K 31075

424230

Procedure for treating acne vulgaris that uses salicylic acid and benzoyl peroxide either sequentially or simultaneously. Compositions for practicing each of these aspects of the invention are also described.

5019569, May 28, 1991

Aug 31, 1989

7/401362

Albert M. Kligman - Philadelphia PA
James A. Mezick - East Brunswick NJ
Robert J. Capetola - Doylestown PA

Ortho Pharmaceutical Corporation - Raritan NJ

A61K 3107, A61K 3156

514171

The present invention is directed to the topical administration of a retinoid-containing pharmaceutical composition for reversing the effects of glucocorticoid-induced skin atrophy.