ALBERT E RAIZNER, MD
Osteopathic Medicine at Fannin St, Houston, TX

6506145, Jan 14, 2003

Jun 6, 1995

08/467711

Anthony J. Bradshaw - Missouri City TX
Steven L. Weinberg - League City TX
Albert E. Raizner - Houston TX

Advanced Cardiovascular Systems, Inc. - Santa Clara CA

A61N 500

600 3

A source wire having a radioactive source at its distal tip is used to treat a blood vessel within a patients body by localized in vivo radiation to prevent stenosis of the blood vessel, including restenosis following percutaneous transluminal coronary angioplasty. The source wire is advanced to the target site along the intravascular system of the patients body from a point external to the body. The source wire is preferably a solid lead of substantially uniform thickness along its entire length, composed of a superelastic nickel-titanium alloy (nitinol). Alternatively, the wire may be a cable composed of multiple strands of the alloy of substantially uniform thickness throughout the entire length of each strand. The alloy has desired characteristics of superelasticity for transitioning into and out of a stress-induced martensitic state as it is advanced through tortuous lumens for passage into the coronary arteries. The wire also is of a diameter suitable for passage into the coronary arteries, and the distal end of the wire may be tapered for ease of entry into narrowed portions.

6283910, Sep 4, 2001

Feb 7, 1996

8/644101

Anthony J. Bradshaw - Missouri City TX
Steven L. Weinberg - League City TX
Albert E. Raizner - Houston TX

A61N 500

600 3

A source wire having a radioactive source at its distal tip is used to treat tissue at a target site within a patient's body by localized in vivo radiation. The source wire is advanced to the target site along the intravascular system of the patient's body from a point external to the body. The source wire is a solid lead of substantially uniform thickness along its entire length, composed of nickel-titanium alloy (nitinol). Alternatively, the wire may be a cable composed of multiple strands of the alloy of substantially uniform thickness throughout the entire length of each strand. The alloy has desired characteristics including flexibility, springiness, slipperiness, mechanical strength and shape memory retention, and the source wire is imparted with certain stressed and unstressed states that depend on flexation of the wire and a prescribed transition temperature. The wire has a diameter suitable for passage into the coronary arteries, and the distal end of the wire is tapered for ease of entry into narrowed portions. The tissue to be treated lies along a portion of the interior surface of a coronary artery which has been subjected to an angioplasty procedure to reduce blockage of the lumen and thereby improve blood flow.

2002006, May 30, 2002

Sep 4, 2001

09/944200

Anthony Bradshaw - Missouri City TX, US
Steven Weinberg - League City TX, US
Albert Raizner - Houston TX, US
John Edison - Houston TX, US

A61N005/00

600/003000

A method is disclosed to treat the wall of a blood vessel from within the lumen thereof with a radiation catheter that includes a working or radiotherapy lumen, a longitudinally channeled distal balloon, and a balloon inflation lumen. The method includes steps of inserting the catheter into the vessel lumen until the balloon is adjacent a target site of the vessel wall to be treated, inflating the balloon to substantially center the catheter radiotherapy lumen within the vessel lumen at the target site while allowing perfusion of blood past the inflated balloon through channels formed by the balloon, advancing a radioactive source into the catheter radiotherapy lumen to position the source within a region of that lumen along a portion of the catheter occupied by the balloon; and withdrawing the source after it has been positioned within that region of the radiotherapy lumen for a predetermined interval of time.

4651738, Mar 24, 1987

Aug 2, 1985

6/762081

Linda L. Demer - Houston TX
Avanindra Jain - Houston TX
Albert E. Raizner - Houston TX
Craig J. Hartley - Houston TX

Baylor College of Medicine - Houston TX

A61M 2902

128344

A novel method and device for performing percutaneous transluminal angioplasty to treat occlusive artery disease is disclosed. The method involves simultaneous measurement and display of the fluid pressure and volume existing within the balloon catheter as the procedure is performed. Information is produced which is useful in determining the efficacy of the procedure as it is performed which obviates the need for arbitrary repeated inflations. The information is also useful in the subsequent management of the patient's disease.

6290949, Sep 18, 2001

May 28, 1996

8/653824

Brent A. French - Houston TX
Albert E. Raizner - Houston TX
Robert Roberts - Houston TX

A61K 4800, A01N 6300, C12N 1500

424 932

Gene transfer vectors, especially adenoviral vectors, and synthetic vectors capable of emulating specific viral functions, that carry gene sequences capable of ameliorating or preventing the symptoms of cardiovascular disease are disclosed. Such methods can be used to treat restenosis, especially when incident to injury by angioplasty.

5643171, Jul 1, 1997

Nov 15, 1994

8/339950

Anthony J. Bradshaw - Missouri City TX
Albert E. Raizner - Houston TX

NeoCardia, LLC - Houston TX

A61N 500

600 1

A method and apparatus for intravascular radiotherapy for prevention of stenosis following angioplasty or other trauma to coronary arteries caused by smooth muscle cell hyperplasia in which a uniform dosage of radiation is delivered to the walls of the artery by positively positioning a radioactive source at the radial center of the artery being treated.