DR. ALAN MAISEL, MD
Osteopathic Medicine at La Jolla Village Dr, San Diego, CA

2012009, Apr 19, 2012

Apr 17, 2010

13/264935

Francisco Villareal - Chula Vista CA, US
Pam R. Taub - Rancho Santa Fe CA, US
Alan S. Maisel - Solana Beach CA, US
George F. Schreiner - Los Altos Hills CA, US
Anne Murphy - Encinitas CA, US
Katrina Yamazaki - Diamond Bar CA, US
Guillermo Ceballos - Lindavista, MX

A61K 31/353, A61P 3/00, A61P 9/12, A61P 13/12, A61P 7/00, A61P 9/04, A61P 3/04, A61P 5/48, A61P 21/00, A61K 31/4406, A61P 25/28

514355, 514456

The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to stimulate mitochondrial function in cells. The methods and compositions described herein provide for reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion (IR) event or method for delaying, attenuating or preventing adverse cardiac remodeling, and can assist in prevention of impaired mitochondria biogenesis and thus prevention of the consequences of impaired mitochondrial biogenesis in various diseases and conditions, as well as provide for the active therapy of mitochondrial depletion that may have already occurred.

2004020, Oct 14, 2004

Dec 3, 2003

10/728067

Kenneth Buechler - Rancho Santa Fe CA, US
Alan Maisel - Solana Beach CA, US

Biosite, Inc.

G01N033/53, G01N033/537, G01N033/543

435/007920

The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.

8648059, Feb 11, 2014

Mar 12, 2009

12/922170

Francisco Villarreal - Chula Vista CA, US
Katrina Go Yamazaki - La Jolla CA, US
Pam Rajendran Taub - San Diego CA, US
Alan Maisel - Solana Beach CA, US

The Regents of the University of California - Oakland CA

A61K 31/65

514152, 514154

The disclosure provides a method of reducing infarct size in the heart following permanent ischemia or ischemia/reperfusion (IR) event or method for delaying, attenuating or preventing adverse cardiac remodeling comprising administering a drug selected from the group consisting of epicatechin, derivatives thereof and pharmaceutically acceptable salts thereof, wherein the subject is a human or a veterinary animal. Additionally the disclosure provides a method of treating subarachnoid hemorrhage or atrial fibrillation or of enhancing or preserving migration, seeding, proliferation, differentiation and/or survival of stem cells in injured heart tissue comprising administering a drug selected from the group consisting of epicatechin, derivatives thereof and pharmaceutically acceptable salts thereof. The effects of epicatechin administration are sustained over time.

2013017, Jul 4, 2013

Jun 5, 2012

13/489317

Francisco Villarreal - Chula Vista CA, US
Alan Maisel - Solana Beach CA, US
George Schreiner - Los Altos Hills CA, US
Guillermo M. Ceballos Reyes - Medico D.F., MX
Pam Taub - Rancho Santa Fe CA, US

A61K 31/455, A61K 31/573, A61K 45/06, A61K 31/353

424649, 514456, 514355, 514220, 51425941, 51421113, 514 50, 514330, 514369, 514 34, 514350, 514158, 514420, 5142265, 514342, 514354, 514274, 514 49, 51425405, 5142634, 514 45, 51425407, 514 81, 514 40, 514 205, 514110, 514171

The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to ameliorate mitochondrial toxicity caused by administration of a chemical, food, or drug.