AKIHIRO HASHIMOTO
Pilots at Laurel St, Branford, CT
License number
Connecticut A4135969
Issued Date
Dec 2015
Expiration Date
Dec 2016
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
47 Laurel St, Branford, CT 06405
Professional information
8A,9-Dihydro-4Ah-Isothiazolo[5,4-B]Quinoline-3,4-Diones And Related Compounds As Anti-Infective Agents
US Patent:
2006010, May 11, 2006
Filed:
Nov 10, 2005
Appl. No.:
11/271556
Inventors:
Barton Bradbury - Wallingford CT, US
Milind Deshpande - Madison CT, US
Michael Pucci - Kensington CT, US
Qiuping Wang - Bethany CT, US
Jason Wiles - Hamden CT, US
Yongsheng Song - Guilford CT, US
Akihiro Hashimoto - Branford CT, US
Edlaine Lucien - New Haven CT, US
Milind Deshpande - Madison CT, US
Michael Pucci - Kensington CT, US
Qiuping Wang - Bethany CT, US
Jason Wiles - Hamden CT, US
Yongsheng Song - Guilford CT, US
Akihiro Hashimoto - Branford CT, US
Edlaine Lucien - New Haven CT, US
International Classification:
A61K 31/496, A61K 31/4745, C07D 498/02
US Classification:
514253030, 514291000, 544361000, 546083000
Abstract:
The invention provides compounds and salts of Formula I and Formula II:
which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables n, m, p, R, R, A, R, R, R, R, R, Aand Rare defined herein.
Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in eukaryotes.
4-Substituted-1H-Isothiazolo[5,4-B][1,4]Oxazino[2,3,4-Ij]Quinoline-7,8(2H,9H)-Diones And Related Compounds As Anti-Infective Agents
US Patent:
2009001, Jan 8, 2009
Filed:
Apr 23, 2008
Appl. No.:
12/108106
Inventors:
Barton James Bradbury - Wallingford CT, US
Milind Deshpande - Madison CT, US
Akihiro Hashimoto - Branford CT, US
Ha Young Kim - Cheshire CT, US
Edlaine Lucien - New Haven CT, US
Godwin Pais - Hamden CT, US
Michael John Pucci - Kensington CT, US
Qiuping Wang - Bethany CT, US
Jason Allan Wiles - Hamden CT, US
Milind Deshpande - Madison CT, US
Akihiro Hashimoto - Branford CT, US
Ha Young Kim - Cheshire CT, US
Edlaine Lucien - New Haven CT, US
Godwin Pais - Hamden CT, US
Michael John Pucci - Kensington CT, US
Qiuping Wang - Bethany CT, US
Jason Allan Wiles - Hamden CT, US
Assignee:
ACHILLION PHARMACEUTICALS, INC. - New Haven CT
International Classification:
A61K 31/5383, C07D 498/06, A61P 33/02, A61P 31/04
US Classification:
5142295, 544 99
Abstract:
The present invention provides compounds of the formula that possess antimicrobial activity. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity. Particular compounds provided herein are also potent and/or selective inhibitors of microbial DNA synthesis and reproduction. The invention provides anti-microbial compositions, including pharmaceutical compositions, containing a compound of the invention and one or more or more carriers. The invention provides pharmaceutical compositions containing a 4-substituted-H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound as the only active agent or in combination with one or more other active agents. The invention provides methods for treating or preventing microbial infections, preferably animals, by administering an effective amount of a 4-substituted-H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound to an organism suffering from or susceptible to microbial infection. The invention also provides methods of inhibiting microbial growth and survival by applying an effective amount of a 4-substituted-H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound.
8-N-Substituted-2H-Isothiazolo[5,4-B]Quinolizine-3,4-Diones And Related Compounds As Antiinfective Agents
US Patent:
7199128, Apr 3, 2007
Filed:
Feb 1, 2006
Appl. No.:
11/345201
Inventors:
Barton J. Bradbury - Wallingford CT, US
Jason Allan Wiles - Hamden CT, US
Milind Deshpande - Madison CT, US
Qiuping Wang - Bethany CT, US
Akihiro Hashimoto - Branford CT, US
Edlaine Lucien - New Haven CT, US
Jason Allan Wiles - Hamden CT, US
Milind Deshpande - Madison CT, US
Qiuping Wang - Bethany CT, US
Akihiro Hashimoto - Branford CT, US
Edlaine Lucien - New Haven CT, US
Assignee:
Achillion Pharmaceuticals, Inc. - New Haven CT
International Classification:
A61K 31/429, A61K 31/424, C07D 498/14, C07D 498/20, C07D 513/14, C07D 513/20, A61P 31/04, C07D 455/02
US Classification:
514278, 546 83, 546115, 514293, 51425303, 544361
Abstract:
The invention provides compounds and salts of Formula I and Formula II:Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of compounds of Formula I and/or Formula II and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.
Subsituted Aliphanes, Cyclophanes, Heteraphanes, Heterophanes, Hetero-Heteraphanes And Metallocenes Useful For Treating Hcv Infections
US Patent:
2012030, Nov 29, 2012
Filed:
May 29, 2012
Appl. No.:
13/482558
Inventors:
Jason Allan Wiles - Madison CT, US
Qiuping Wang - Bethany CT, US
Akihiro Hashimoto - Branford CT, US
Godwin Pais - Hamden CT, US
Xiangzhu Wang - Madison CT, US
Venkat Gadhachanda - Hamden CT, US
Avinash Phadke - Branford CT, US
Milind Deshpande - Madison CT, US
Dawei Chen - Middletown CT, US
Qiuping Wang - Bethany CT, US
Akihiro Hashimoto - Branford CT, US
Godwin Pais - Hamden CT, US
Xiangzhu Wang - Madison CT, US
Venkat Gadhachanda - Hamden CT, US
Avinash Phadke - Branford CT, US
Milind Deshpande - Madison CT, US
Dawei Chen - Middletown CT, US
Assignee:
ACHILLION PHARMACEUTICALS, INC - New Haven CT
International Classification:
A61K 31/4178, A61K 31/4184, C07F 17/02, A61P 31/14, C07D 471/08, A61K 31/439, A61K 31/496, C07D 403/14, A61K 31/555
US Classification:
514186, 5483147, 514397, 5483054, 514394, 548103, 546112, 514299, 544357, 51425211
Abstract:
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula Iuseful as antiviral agents. In certain embodiments disclosed herein M is a group —P-A-P— where A isCertain substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions/ and combinations containing one or more substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes and a pharmaceutically acceptable carrier are also provided by this disclosure. Methods for treating viral infections, including Hepatitis C viral infections are provided by the disclosure.
New Isothiazoloquinolones And Related Compounds As Anti-Infective Agents
US Patent:
2012011, May 10, 2012
Filed:
Jan 12, 2012
Appl. No.:
13/348703
Inventors:
Barton James Bradbury - Wallingford CT, US
Godwin Pais - Hamden CT, US
Quiping Wang - Bethany CT, US
Milind Deshpande - Madison CT, US
Michael Pucci - Kensington CT, US
Yongsheng Song - Guilford CT, US
Edlaine Lucien - New Haven CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Godwin Pais - Hamden CT, US
Quiping Wang - Bethany CT, US
Milind Deshpande - Madison CT, US
Michael Pucci - Kensington CT, US
Yongsheng Song - Guilford CT, US
Edlaine Lucien - New Haven CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Assignee:
Achillion Pharmaceuticals, Inc. - New Haven CT
International Classification:
A61K 31/4745, A61K 31/4375, A61K 38/21, A61P 31/12, A61P 31/04, A61P 33/02, A61P 31/10, A61P 17/00, A61P 13/02, A61P 11/00, A61P 19/08, A61P 19/02, A61P 1/12, C07D 513/14, C07D 513/04
US Classification:
424 854, 546 83, 514293
Abstract:
The invention provides certain compounds and salts of Formula I and Formula II:which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A, R, R, R, R, R, Aand Rare defined herein.Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
Isothiazoloquinolones And Related Compounds As Anti-Infective Agents
US Patent:
2011022, Sep 15, 2011
Filed:
Mar 14, 2011
Appl. No.:
13/047150
Inventors:
Barton James Bradbury - Wallingford CT, US
Milind Deshpande - Madison CT, US
Michael John Pucci - Kensington CT, US
Qiuping Wang - Bethany CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Edlaine Lucien - New Haven CT, US
Milind Deshpande - Madison CT, US
Michael John Pucci - Kensington CT, US
Qiuping Wang - Bethany CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Edlaine Lucien - New Haven CT, US
Assignee:
ACHILLION PHARMACEUTICALS, INC. - New Haven CT
International Classification:
A61K 38/21, C07D 471/04, A61K 31/4738, C07D 413/14, A61K 31/5377, A61K 31/496, A61K 31/497, A61K 31/55, C07D 241/42, A61K 31/498, C07D 403/14, A61K 31/506, A61P 31/04, A61P 31/12, A61P 31/00
US Classification:
424 854, 546 83, 514293, 544126, 5142328, 544361, 51425303, 544405, 51425505, 540597, 51421707, 544353, 514249, 544316, 514274
Abstract:
The invention provides compounds and salts of Formula I and Formulawhich possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A, R, R, R, R, R, Aand Rare defined herein.Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
Method For Synthesis Of 8-Alkoxy-9H-Isothiazolo[5,4-B]Quinoline-3,4-Diones
US Patent:
7902365, Mar 8, 2011
Filed:
Aug 16, 2007
Appl. No.:
11/840006
Inventors:
Barton James Bradbury - Wallingford CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Qiuping Wang - Bethany CT, US
Edlaine Lucien - New Haven CT, US
Godwin Pais - Hamden CT, US
Ha Young Kim - Cheshire CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Qiuping Wang - Bethany CT, US
Edlaine Lucien - New Haven CT, US
Godwin Pais - Hamden CT, US
Ha Young Kim - Cheshire CT, US
Assignee:
Achillion Pharmaceuticals, Inc. - New Haven CT
International Classification:
C07D 215/38
US Classification:
546155, 514312
Abstract:
The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A.
Method For Synthesis Of 8-Alkoxy-9H-Isothiazolo[5,4-B]Quinoline-3,4-Diones
US Patent:
8138346, Mar 20, 2012
Filed:
Mar 4, 2011
Appl. No.:
13/040369
Inventors:
Barton James Bradbury - Wallingford CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Qiuping Wang - Bethany CT, US
Edlaine Lucien - New Haven CT, US
Godwin Pais - Hamden CT, US
Ha Young Kim - Cheshire CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Qiuping Wang - Bethany CT, US
Edlaine Lucien - New Haven CT, US
Godwin Pais - Hamden CT, US
Ha Young Kim - Cheshire CT, US
Assignee:
Achillion Pharmaceuticals, Inc. - New Haven CT
International Classification:
C07D 215/38
US Classification:
546163
Abstract:
The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A.
Hydroxylthienoquinolones And Related Compounds As Anti-Infective Agents
US Patent:
8173636, May 8, 2012
Filed:
Apr 5, 2010
Appl. No.:
12/754057
Inventors:
Barton James Bradbury - Wallingford CT, US
Milind Deshpande - Madison CT, US
Akihiro Hashimoto - Branford CT, US
Ha Young Kim - Cheshire CT, US
Edlaine Lucien - New Haven CT, US
Godwin Pais - Hamden CT, US
Michael Pucci - Kensington CT, US
Qiuping Wang - Bethany CT, US
Jason Allan Wiles - Hamden CT, US
Avinash Phadke - Branfod CT, US
Milind Deshpande - Madison CT, US
Akihiro Hashimoto - Branford CT, US
Ha Young Kim - Cheshire CT, US
Edlaine Lucien - New Haven CT, US
Godwin Pais - Hamden CT, US
Michael Pucci - Kensington CT, US
Qiuping Wang - Bethany CT, US
Jason Allan Wiles - Hamden CT, US
Avinash Phadke - Branfod CT, US
Assignee:
Achillion Pharmaceuticals, Inc. - New Haven CT
International Classification:
C07D 495/04, A61K 31/4743, A61K 31/496
US Classification:
51421021, 514291, 51425303, 546 80, 544361
Abstract:
Disclosed herein are hydroxylthienoquinolones and related compounds and their pharmaceutically acceptable salts useful as antiviral agents and having the general formula.
Isothiazoloquinolones And Related Compounds As Anti-Infective Agents
US Patent:
8114888, Feb 14, 2012
Filed:
Feb 15, 2006
Appl. No.:
11/354521
Inventors:
Barton James Bradbury - Wallingford CT, US
Godwin Pais - Hamden CT, US
Qiuping Wang - Bethany CT, US
Milind Deshpande - Madison CT, US
Michael Pucci - Kensington CT, US
Yongsheng Song - Guilford CT, US
Edlaine Lucien - New Haven CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Godwin Pais - Hamden CT, US
Qiuping Wang - Bethany CT, US
Milind Deshpande - Madison CT, US
Michael Pucci - Kensington CT, US
Yongsheng Song - Guilford CT, US
Edlaine Lucien - New Haven CT, US
Jason Allan Wiles - Hamden CT, US
Akihiro Hashimoto - Branford CT, US
Assignee:
Achillion Pharmaceuticals, Inc. - New Haven CT
International Classification:
A61K 31/4365, A61K 31/4375, C07D 491/14
US Classification:
514293, 546 83
Abstract:
The invention provides certain compounds and salts of Formula I and Formula II:.