Inventors:
Ahmet Hoke - Towson MD, US
Kam W. Leong - Ellicott City MD, US
Sing Yian Chew - Baltimore MD, US
Ruifa Mi - Baltimore MD, US
Assignee:
The John Hopkins University - Baltimore MD
International Classification:
A61F 2/02, A61K 38/02, A61K 31/7088, A61K 31/70, A61K 38/18, A61K 38/19, A61K 39/395, A61K 9/70, A61P 25/00
US Classification:
424423, 514 11, 514 44 R, 514 23, 514 76, 424 851, 4241301, 424400, 977762, 977915
Abstract:
The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.