Inventors:
Alan D. D'Andrea - Winchester MA, US
Patrizia Vinciguerra - Boston MA, US
Stephen J. Elledge - Brookline MA, US
Shuhei Matsuoka - Brookline MA, US
Agata M. Smogorzewska - Boston MA, US
Kay O. Hofmann - Koeln, DE
Assignee:
Miltenyi Biotec GmbH - Bergisch-Gladbach
The Brigham & Women's Hospital, Inc. - Boston MA
International Classification:
G01N 33/68, G01N 33/50, C07K 16/18, A61K 31/713, A61K 45/06, C12N 9/10, A61K 39/395, C12Q 1/68, C12N 15/113
US Classification:
4241391, 435 71, 435 792, 435 611, 435 32, 514 44 A, 435 61, 435193, 536 245
Abstract:
Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention identifies and characterizes the FANCI polypeptide as a vital component of the Fanconi anemia pathway and discloses inhibitors of FANCI and methods of using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer.