Inventors:
Douglas C. Beshore - Lower Gwynedd PA, US
Robert M. Garbaccio - Lansdale PA, US
Scott D. Kuduk - Harleysville PA, US
Adam W. Johnson - Philadelphia PA, US
Jason W. Skudlarek - Audubon PA, US
International Classification:
C07D 413/12, C07D 401/12, C07D 249/18, C07D 401/14, C07D 403/10
US Classification:
5142342, 5462744, 514338, 548261, 514389, 514359, 514384, 5462684, 548248, 514374, 544366, 51425406, 546199, 514322, 544132
Abstract:
The present invention is directed to aminomethyl biaryl benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.