ADAM J CARTER
Broker in Plum Island, MA
License number
Massachusetts 9005151
Issued Date
Nov 5, 1993
Expiration Date
Mar 14, 2000
Type
Salesperson
Address
Address
Plum Island, MA 01950
Professional information
Methods And Compositions For Modulating Responsiveness To Corticosteroids
US Patent:
6054487, Apr 25, 2000
Filed:
Mar 18, 1997
Appl. No.:
8/820692
Inventors:
Les Sekut - Westborough MA
Adam Carter - Newburyport MA
Tariq Ghayur - Grafton MA
Subhashis Banerjee - Shrewsbury MA
Daniel E. Tracey - Harvard MA
Adam Carter - Newburyport MA
Tariq Ghayur - Grafton MA
Subhashis Banerjee - Shrewsbury MA
Daniel E. Tracey - Harvard MA
Assignee:
BASF Aktiengesellschaft - Rheinland Pfalz
International Classification:
A61K 3118
US Classification:
514604
Abstract:
Method for modulating responsiveness to corticosteroids in a subject are provided. In the method of the invention, an agent which antagonizes a factor that regulates production of IFN-. gamma. in the subject is administered to the subject in combination with a corticosteroid such that responsiveness of the subject to the corticosteroid is modulated as compared to when a corticosteroid alone is administered to the subject. In one embodiment, the agent is an interferon-. gamma. inducing factor (IGIF) antagonist. In another embodiment, the agent is an interleukin-12 (IL-12) antagonist. In a preferred embodiment, the agent is an inhibitor of a caspase family protease, preferably an ICE inhibitor. In another preferred embodiment, the agent is an anti-IL-12 monoclonal antibody. Other preferred agents include phosphodiesterase IV inhibitors and beta-2 agonists.