Inventors:
Alexander DePaoli - Santa Barbara CA, US
Simeon Taylor - Skillman NJ, US
Elif Oral - Ann Arbor MI, US
Abhimanyu Garg - Dallas TX, US
Assignee:
Amgen, Inc. - Thousand Oaks CA
The Govt. of the U.S.A. as represented by the Secretary, Dept. of Health & Human Services - Rockville MD
Board of Regents, The University of Texas System - Austin TX
International Classification:
A61K 38/17
Abstract:
Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including subcutaneously and using gene therapy methods. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having a leptin level of approximately 4 ng/ml or less before treatment.