Inventors:
Lakshmi Khandke - Nanuet NY, US
Abbas Rashidbaigi - Basking Ridge NJ, US
International Classification:
A61K 39/385, A61M 5/24, A61M 5/31
Abstract:
An immunogenic composition comprising a plurality of capsular polysaccharides from serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F conjugated to a carrier protein, and further comprising at least one preservative, preferably 2-phenoxyethanol (2-PE). The preservative-containing immunogenic compositions of the invention confer resistance to one or more micro-organisms and are useful for producing multi-dose vaccine formulations having advantageous properties with respect to long term stability of the different antigenic determinants in the immunogenic composition of choice. Related compositions and methods for measuring the efficacy of one or more preservatives in a vaccine formulation are also provided.