Inventors:
Zhi-Jie Ni - Emeryville CA, US
Sabina Pecchi - Emeryville CA, US
Matthew Burger - Emeryville CA, US
Wooseok Han - Emeryvile CA, US
Aaron Smith - Emeryville CA, US
Gordana Atallah - Emeryville CA, US
Sarah Bartulis - Emeryville CA, US
Kelly Frazier - Emeryville CA, US
Joelle Verhagen - Emeryville CA, US
Yanchen Zhang - Emeryville CA, US
Ed Iwanowicz - Emeryville CA, US
Tom Hendrickson - Emeryville CA, US
Mark Knapp - Emeryville CA, US
Hanne Merritt - Emeryville CA, US
Charles Voliva - Emeryville CA, US
Marion Wiesmann - Emeryville CA, US
Darren Mark Legrand - West Sussex, GB
Ian Bruce - West Sussex, GB
James Dale - West Sussex, GB
Jiong Lan - Emeryville CA, US
Barry Levine - Emeryville CA, US
Abran Costales - Emeryville CA, US
Jui Liu - Emeryville CA, US
Teresa Pick - Emeryville CA, US
Daniel Menezes - Emeryville CA, US
International Classification:
A61K 31/5377, C07D 471/04, C07D 487/04, C07D 413/14, A61K 31/437, A61K 31/5025, A61P 35/00
US Classification:
5142358, 546121, 544236, 544121, 514300, 514248
Abstract:
Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.