Inventors:
George Eisenbarth - Golden CO, US
Aaron Michels - Aurora CO, US
David Ostrov - Gainesville FL, US
Maki Nakayama - Denver CO, US
International Classification:
A61K 31/44, A61K 31/663, A61K 31/194, A61K 31/198, A61K 31/351, A61P 3/10, A61K 31/47, A61K 31/4965, A61K 31/661, A61K 31/185, A61K 31/4172, A61P 37/06, A61K 31/662, A61K 31/222
Abstract:
The invention provides methods of preventing, treating or ameliorating autoimmune diseases such as diabetes by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.