AARON G OSBORNE
Osteopathic Medicine at Denver Ave, Tulsa, OK
License number
Florida 1044
Issued Date
Oct 13, 2003
Effective Date
Aug 3, 2016
Expiration Date
Oct 13, 2004
Category
Health Care
Type
Osteopathic Resident Registration
Address
Address
2
1000 S Denver Ave, Tulsa, OK 74119
4 Columbia Dr STE 710, Tampa, FL 33606
4 Columbia Dr STE 710, Tampa, FL 33606
Personal information
See more information about AARON G OSBORNE at radaris.comName
Address
Phone
1000 S Denver Ave APT 5104, Tulsa, OK 74119
440 Arizona Ave, Fort Lauderdale, FL 33312
10814 N Teegreen Rd, Tampa, FL 33612
18232 Clear Lake Dr, Lutz, FL 33548
816 20Th St, Oklahoma City, OK 73105
Professional information
See more information about AARON G OSBORNE at trustoria.com
Oct-1 As An Oncoprotein And Use Of Nucleic Acid Inhibitors Of Oct-1 For Cancer Treatment
Oct-1 As An Oncoprotein And Use Of Nucleic Acid Inhibitors Of Oct-1 For Cancer Treatment
US Patent:
7601696, Oct 13, 2009
Filed:
Aug 23, 2004
Appl. No.:
10/711101
Inventors:
George Blanck - Tampa FL, US
Kimberly Palubin - Atlanta GA, US
Aaron Osborne - Tampa FL, US
Kimberly Palubin - Atlanta GA, US
Aaron Osborne - Tampa FL, US
Assignee:
University of South Florida - Tampa FL
International Classification:
A61K 31/70, C07H 21/04, C12N 15/00
US Classification:
514 44, 536 231, 536 245, 4353201
Abstract:
Oct-1 is shown to be an oncoprotein because of its known role as an activator of the histone H2B gene and the importance of this gene during DNA synthesis. To determine the role of Oct-1 as an oncoprotein, the cell line 5637 (ATCC HTB9) was transfected with the vector pcDNA3 containing full length, antisense Oct-1 cDNA. This cell line is Rb-defective and has been shown to have increased Oct-1 binding activity as compared to Rb reconstituted clones. After transfection, Oct-1 antisense clones were grown and assayed for the loss of oncogenic characteristics as compared to control transformants.