MR. AARON C JONES, AU.D.
Audiology at Santa Fe Dr, Encinitas, CA

2009002, Jan 22, 2009

Jun 17, 2008

12/140940

Michal Lebl - San Diego CA, US
Mark S. Chee - Encinitas CA, US
Steven M. Barnard - San Diego CA, US
David L. Heiner - San Diego CA, US
Vit Pokorny - Praha, CZ
Mark J. Nibbe - Oceanside CA, US
Aaron Christopher Jones - San Diego CA, US

C40B 50/08, C40B 60/14

506 27, 506 40

An apparatus for high-throughput combinatorial synthesis of organic molecules including a reaction vessel for containing a combinatorial chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis or rotation. A method of combinatorial synthesis of organic molecules is also disclosed.

7025935, Apr 11, 2006

Apr 11, 2003

10/412636

Aaron C. Jones - San Diego CA, US
Brett C. Ellman - San Diego CA, US

Illumina, Inc. - San Diego CA

B01L 3/02, G01N 1/10, G01N 21/00, G01N 15/06, G01N 35/00

422100, 422 58, 422 681, 436180, 436 46

The invention provides an apparatus and method for transferring a plurality of samples from an array of source sample locations to an array of destination sample locations. An apparatus or method of the invention are useful for reformatting samples in cases where the array of source sample locations differs in shape or orientation from the array of destination sample locations. The invention can be used to transfer fluid samples in the absence of an externally applied force. Because active automation is not required for transferring samples, the invention provides the advantage of a compact and efficient format for liquid handling.

2007011, May 24, 2007

Sep 13, 2006

11/521574

David Heiner - San Diego CA, US
Aaron Jones - San Diego CA, US
Steven Fambro - Carlsbad CA, US
Mark Nibbe - San Diego CA, US
Steven Burgett - San Diego CA, US
Brett Ellman - Cardiff CA, US
Michal Lebl - San Diego CA, US

C12M 3/00, C12P 21/06, C12P 19/34

435068100, 435091200, 435289100

Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.

7914739, Mar 29, 2011

Sep 13, 2006

11/521573

David L. Heiner - San Diego CA, US
Aaron C. Jones - San Diego CA, US
Steven P. Fambro - Carlsbad CA, US
Mark J. Nibbe - San Diego CA, US
Steve R. Burgett - San Diego CA, US
Brett M. Ellman - Cardiff CA, US
Michal Lebl - San Diego CA, US

Illumina, Inc. - San Diego CA

G01N 21/00

422 64, 422 50, 422 72, 422 8205, 436 50, 436 55

Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.