A. WAYNE MEIKLE, MD
Osteopathic Medicine at Arapeen Dr, Salt Lake City, UT
License number
Utah 150192-1205
Category
Osteopathic Medicine
Type
Endocrinology, Diabetes & Metabolism
Address
Address
615 Arapeen Dr, Salt Lake City, UT 84108
Phone
(801) 581-7761
(801) 213-3800
(801) 213-3800
Personal information
See more information about A. WAYNE MEIKLE at radaris.comName
Address
Phone
S Salt Lake, UT
Professional information
Methods For Analysis Of Free And Autoantibody-Bound Biomarkers And Associated Compositions, Devices, And Systems
US Patent:
2013018, Jul 18, 2013
Filed:
Nov 14, 2012
Appl. No.:
13/676980
Inventors:
University of Utah Research Foundation - Salt Lake City UT, US
Alan L. Rockwood - Riverton UT, US
A. Wayne Meikle - Salt Lake City UT, US
Alan L. Rockwood - Riverton UT, US
A. Wayne Meikle - Salt Lake City UT, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
G01N 33/53
US Classification:
436501, 422430
Abstract:
The present invention provides methods, compositions, and kits associated with analyzing, enriching, and/or isolating a biomarker or analyte in a biological sample. In one aspect, for example, a method for determining a concentration of a biomarker in a biological sample can include binding any unbound biomarker with an antibody specific for the biomarker to form antibody-bound biomarker, enriching the antibody-bound biomarker and any endogenous autoantibody-bound biomarker to form an enriched fraction, identifying the biomarker in the enriched fraction, and determining the concentration of the biomarker in the biological sample. In one aspect, the concentration of the biomarker is derived from initially unbound biomarker and autoantibody-bound biomarker in the biological sample.
Methods And Compositions For Detecting Steroids
US Patent:
2009003, Feb 5, 2009
Filed:
Aug 4, 2005
Appl. No.:
11/631725
Inventors:
A. Wayne Meikle - Salt Lake City UT, US
David J. Stillman - Salt Lake City UT, US
Alan H. Terry - Bountiful UT, US
Jared M. Orrock - Salt Lake City UT, US
Tanya M. Sandrock - Salt Lake City UT, US
David J. Stillman - Salt Lake City UT, US
Alan H. Terry - Bountiful UT, US
Jared M. Orrock - Salt Lake City UT, US
Tanya M. Sandrock - Salt Lake City UT, US
Assignee:
The University of Utah - Salt Lake City UT
International Classification:
C12Q 1/68, C12N 15/00, C12N 1/19
US Classification:
435 6, 4353201, 4352542
Abstract:
The present invention provides for methods and systems for detecting steroids. Examples of such steroids include estrogen, progesterone, androgen, testosterone, and derivatives and analogs thereof. Systems useful for carrying out the method include tripartite constructs including a DNA-binding domain, a ligand binding domain, and an activation domain. The present invention provides numerous improvements over previous diagnostic systems for detection of steroids, such advantages include that the method allows for detection of steroid analogs and derivatives, whose structures may not yet be known, the method is generally applicable to a wide variety of organisms, and numerous ligand binding domains may be used in conjunction with the present system.