Inventors:
Stephen Davis - Durham NC, US
Scott Dickerson - Chapel Hill NC, US
Stephen Frye - Durham NC, US
Philip Harris - Raleigh NC, US
Robert Hunter - Raleigh NC, US
Lee Kuyper - Durham NC, US
Karen Lackey - Hillsborough NC, US
Michael Luzzio - Groton CT, US
James Veal - Apex NC, US
Duncan Walker - Summit NJ, US
International Classification:
C 07D 4 3/02, C 07D 2 9/56, C07D209/34
US Classification:
546/200000, 548/361100, 548/432000, 548/486000
Abstract:
Compounds of formula (I): wherein X is N, CH, CCF, or C(Caliphatic); Ris sulfonic acid, Caliphatic-sulfonyl, sulfonyl-Caliphatic, Caliphatic-sulfonyl-Caliphatic, Caliphatic-amino, R-sulfonyl, Rsulfonyl-Caliphatic, R-aminosulfonyl, R-aminosulfonyl-Caliphatic, R-sulfonylamino, R-sulfonylamino-Caliphatic, aminosulfonylamino, di-Caliphatic amino, di-Caliphatic aminocarbonyl, di-Claliphatic aminosulfonyl, di-Caliphatic amino, di-Caliphatic aminocarbonyl, di-Caliphatic aminosulfonyl-Caliphatic, (R)-Arylamino, (R)-Arylsulfonyl, (R)-Aryl-aminosulfonyl, (R)-Aryl-sulfonylamino, Het-amino, Het-sulfonyl, Het-aminosulfonyl, aminoiminoamino, or aminoiminoaminosulfonyl, Ris hydmogen; and further wherein Rand Rare optionally joined to form a fused ring, pharmaceutical formulations comprising them and their use in therapy, especially in the treatment of diseases mediated by CDK2 activity, such as alopecia induced by cancer chemotherapy or radiotherapy.